نتایج جستجو برای: ag490

تعداد نتایج: 313  

Journal: :Oncology reports 2010
Tomoaki Terakawa Hideaki Miyake Masafumi Kumano Iori Sakai Masato Fujisawa

The objective of this study was to assess the effect of antiandrogen on the activation of mutated androgen receptor (AR) and its signaling pathway in prostate cancer. We transfected the AR gene with a point mutation at codon 741 (tryptophan to leucine; W741L) into human androgen-independent prostate cancer PC3 cells lacking the expression of AR, and established PC3 cells overexpressing mutant t...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012
Yuanyuan Ji Zhidong Wang Zongfang Li Ke Li Xiaofeng Le Ting Zhang

Angiotensin II (Ang II) has been shown to function as a key role in neovascularization of hepatocellular carcinoma (HCC), but little is known its underlying mechanisms. The aim of this study was to explore the role of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway in Ang II-induced HCC angiogenic factors production. Herein, we found that Ang II upregu...

2013
Weixun Duan Yang Yang Wei Yi Juanjuan Yan Zhenxin Liang Ning Wang Yue Li Wensheng Chen Shiqiang Yu Zhenxiao Jin Dinghua Yi

Previous studies have shown that the JAK2/STAT3 signaling pathway plays a regulatory role in cellular oxidative stress injury (OSI). In this study, we explored the role of the JAK2/STAT3 signaling pathway in hydrogen peroxide (H2O2)-induced OSI and the protective effect of melatonin against (H2O2)-induced injury in human umbilical vein endothelial cells (HUVECs). AG490 (a specific inhibitor of ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2005
Jin Qiu William B J Cafferty Stephen B McMahon Stephen W N Thompson

Sensory axons in the adult spinal cord do not regenerate after injury. This is essentially because of inhibitory components in the damaged CNS, such as myelin-associated inhibitors and the glial scar. However, if the sciatic nerve is axotomized before injury of the dorsal column, injured axons can regenerate a short distance in the spinal cord. Here, we show that sciatic nerve transection resul...

Journal: :Biochemical and Biophysical Research Communications 2009

Journal: :Food and Agricultural Immunology 2022

To explore the involved mechanisms and possible treatments of ambient PM2.5 exposure-induced lung inflammation, this work studied activity luteolin, a natural flavonoid which widely presents in many plant species, murine alveolar macrophage MH S cells exposed to PM2.5. Results showed induced an inflammatory response, as evidenced by significantly increased TNF-α, IL-6, MCP-1 Rantes levels. iNOS...

Journal: :Circulation research 2015
Andreas Skyschally Sabine Gent Georgios Amanakis Christiane Schulte Petra Kleinbongard Gerd Heusch

RATIONALE Reduction of myocardial infarct size by remote ischemic preconditioning (RIPC), that is, cycles of ischemia/reperfusion in an organ remote from the heart before sustained myocardial ischemia/reperfusion, was confirmed in all species so far, including humans. OBJECTIVE To identify myocardial signal transduction of cardioprotection by RIPC. METHODS AND RESULTS Anesthetized pigs were...

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