It has been shown previously that aerobic actinomycetes can be separated into four main groups on the basis of their cell wall composition. Six representatives of aerobic actinomycetes (Nocardia asteroides and Micropolyspora brevicatena, cell wall type IV; N. madurae, Microbispora rosea, cell wall type III; Actinoplanes sp., cell wall type II; Streptomyces griseus, cell wall type I) were subjec...

N-Methyl-4-nitroaniline (MNA) is used as an additive to lower the melting temperature of energetic materials in the synthesis of insensitive explosives. Although the biotransformation of MNA under anaerobic condition has been reported, its aerobic microbial degradation has not been documented yet. A soil microcosms study showed the efficient aerobic degradation of MNA by the inhabitant soil mic...

Aerobacter aerogenes strain 1033 can utilize glycerol as sole source of carbon and energy under aerobic and anaerobic conditions (2). With the aid of isotope enantiomorphs of glycerol1-V it could be shown that an important pathway of glycerol metabolism in this organism involves dihydroxyacetone as an intermediate between glycerol and pyruvate (3). The validity of this conclusion was strengthen...

We have observed the selective toxicity of mitomycin C toward hypoxic as compared to aerobic cells in vitro for three established cell lines (Chinese hamster ovary, Chinese hamster V-79, and human HeLa) and for cells from the transplantable KHT murine tumor. The magnitude of the selective toxicity was cell line dependent. We have studied the in vivo effects of mitomycin C against aerobic and hy...

The percentage pollutant removal obtained by the previous work were very good in terms of BOD5 which was 95% removal, TSS 97% but unsatisfactory NH4-N, NO3-N and P 39%, 41% 44% respectively-The effect recycling portion effluent discharged from 2ND. Cell, a VSSF constructed wetland back to 1ST. cell on nutrient efficiency studied this research.The intermittent feeding influent recycled quantity ...

Reaction constants and heat release during thermophilic aerobic digestion of typical secondary and mixed sludges were determined. Maximum reaction constant, determined by measuring the amounts of biodegradable volatile suspended solids (bVSS) removed, occurred in the temperature range of 55-60 ºC. Measurement of heat releases were carried out, at the same range, by the aid of a temperature ...

Paired samples of an intact rabbit aortic intima-media preparation were incubated for short periods under aerobic or anoxic conditions in Krebsbicarbonate buffer containing 6% albumin and 5 mM glucose. During aerobic incubation for as long as 1 h the preparation retained an electron microscopic (EM) appearance similar to that of tissue fixed in situ, and scanning EM confirmed the presence of an...

Pancreatic cancer is a fatal malignancy worldwide and urgently requires valid therapies. Previous research showed that the HDAC inhibitor chidamide is a promising anti-cancer agent in pancreatic cancer cell lines. In this study, we elucidate a probable underlying anti-cancer mechanism of chidamide involving the degradation of Mcl-1. Mcl-1 is frequently upregulated in human cancers, which has be...

We investigated whether altering Warburg metabolism (aerobic glycolysis) by treatment with the metabolic agent dichloroacetate (DCA) could increase the X-ray-induced cell killing of the radiation-resistant human non-small-cell lung cancer (NSCLC) cell lines A549 and H1299. Treatment with 50mM DCA decreased lactate production and glucose consumption in both A549 and H1299, clear indications of a...

PURPOSE To characterize the response of cultured human retinal pigment epithelial (RPE) cells to lowered environmental oxygen. METHODS The response of cultured RPE cells to lowered oxygen environments was compared to that of cell types of presumed high (Madin-Darby canine kidney [MDCK] cells, an epithelial cell line) and low (CSF, corneal stromal fibroblasts) aerobic requirements. Cultures in...