Bortezomib is a chemotherapeutic drug used in the treatment of multiple myeloma and amyloidosis. The major dose limiting adverse effect neuropathy.

We consider the accumulation of deleterious mutations in an asexual population, a phenomenon known as Muller’s ratchet, using the continuous time model proposed in [4]. We show that for any parameter λ > 0 ( the rate at which mutations occur), for any α > 0 ( the toxicity of the mutations) and for any size N > 0 of the population, the ratchet clicks a.s. in finite time. That is to say the minim...

background: we aimed to explore whether maternal asymptomatic hepatitis b (hb) infection effects on pre-term rupture of membranous (prom), stillbirth, preeclampsia, eclampsia, gestational hypertension, or antepartum hemorrhage. methods: we searched the pubmed, scopus, and isi web of science from 1990 to feb 2015. in addition, electronic literature searches supplemented by searching the gray lit...

a bstract background: medication errors and adverse drug events of high alert medication are one of the major problems in therapeutic system. the purpose of the present study was to investigate ‎the effect of clinical supervision model on high alert medication safety in intensive care units nurses. materials and methods: this was a quasi-experimental study conducted on 32 nurses of intensive ca...

introduction: amodiaquine is a partner drug in the artemisinin-based combination therapy artesunate-amodiaquine. reports of the adverse drug reaction known as amodiaquine-associated asthenia are scarce, and this adverse reaction needs to be investigated in detail. this article presents and reviews a case of amodiaquine-associated asthenia. a literature search for the characteristics of this adv...

BACKGROUND Adverse drug events and medication errors are threats to quality care. Inpatient studies suggest that a pharmacist may reduce these events, but outpatient studies have not been forthcoming. METHODS We conducted a pooled analysis of 2 randomized controlled trials to determine the effect of pharmacist intervention on adverse drug events and medication errors. We studied 800 outpatien...