BACKGROUND The role of advanced maternal age as a risk factor for congenital malformations in offspring is known. However, the influence of paternal age is not clear. AIM To evaluate the association between advanced paternal age and the risk for congenital malformations. PATIENTS AND METHODS Analysis of maternal and paternal age of cases (malformed newborns) and controls from ECLAMC Databas...

OBJECTIVE To assesses pregnancy outcomes in women of extremely advanced maternal age (> or = 45 years). MATERIAL AND METHOD Computerized delivery records, collected between January 2002 and December 2012 at Rajavithi Hospital, were retrospectively reviewed We compared the condition of women of maternal age > or = 45 years with singleton delivery and beyond 24 weeks of gestation (n = 82) in a ...

Background Studies on advanced maternal age-defined here as age 35 or older-and children's cognitive ability report mixed evidence. Previous studies have not analysed how the time period considered in existing studies influences the association. Methods We analysed trends in the association between maternal age and cognitive ability using data from the 1958 National Child Development Study ( ...

Aneuploidy in human eggs is the leading cause of pregnancy loss and Down's syndrome. Aneuploid eggs result from chromosome segregation errors when an egg develops from a progenitor cell, called an oocyte. The mechanisms that lead to an increase in aneuploidy with advanced maternal age are largely unclear. Here, we show that many sister kinetochores in human oocytes are separated and do not beha...

Introduction Improved fertility treatment options and a change in the socio-cultural concept of family planning, especially in industrialized regions, has led to an increasing number of births by women of advanced maternal age, which is associated with a higher rate of complications. The aim of this study was to analyze pregnancy outcomes in women aged ≥ 45 years in an inner-city German hospita...