A 46-year-old man presented with a huge splenic artery dissecting aneurysm that had been incidentally found and was successfully resected before rupture. The histopathologic findings were compatible with segmental mediolytic arteriopathy (SMA). Simultaneous involvement of the left renal and right common iliac artery was observed. The patient was also found to have an adrenocortical adenoma, gas...

A 28-year-old man with bilateral central serous chorioretinopathy (CSCR) and body weight gain was diagnosed with Cushing's syndrome secondary to an adrenocortical adenoma. The patient had high levels of free cortisol and the tumor was confirmed by histopathology. After surgery, cortisol levels decreased and the CSCR spontaneously resolved. This case highlights the role of cortisol in the pathog...

Adrenocortical tumors (ACT) include both adrenocortical adenomas (ACA) and adrenocortical carcinomas (ACC). Carcinomas are rare in children and adolescents. In the United States, Surveillance Epidemiology and End Results (SEER) data from the National Cancer Institute show that the proportion of adrenocortical tumors (ACT) in childhood carcinoma is only about 1.3%, and the proportion of ACT in c...

cases of endogenous CS are related to excessive adrenocorticotrophin (ACTH) production, most commonly from a pituitary adenoma, or from a non-pituitary tumour (ACTH-dependent CS). Less often endogenous CS is secondary to hyperfunctioning adrenocortical tumours, bilateral adrenal hyperplasia, and/or dysplasia (ACTH-independent CS). Endogenous CS needs to be distinguished from the so-called ‘pseu...

primary hyperaldosteronism is one of the few causes of hypertension that can be cured by surgery. primary hyperaldosteronism is caused by adrenocortical adenoma or hyperplasia. it is important to differentiate between adrenal adenoma and hyperplasia because the preferred treatments are different. in all patients with new-onest or worsening hypertension the primary hyperaldosteronism should be c...