We present a clinical observation of patient whose cause death was new coronavirus infection COVID-19 complicated by bilateral viral interstitial pneumonia and adult acute respiratory distress syndrome. The presence background diseases-rheumatoid arthritis secondary AA-adrenal amyloidosis-worsened the prognosis. Waterhouse-Friderichsen syndrome with hemorrhage foci necrosis in adrenal cortex de...

The authors conducted an experimental study in male human volunteers to examine the effects of a neurokinin type 1 receptor (NK1R) antagonist on aldosterone secretion. findings show presence Substance P (SP)-positive nerve fibres adrenal cortex vicinity aldosterone-producing cells and with role mineralocorticoid synthesis.

The adrenal gland plays essential roles in the control of body homeostasis, stress, and immune responses. The adrenal cortex represents up to 90% of the gland and is specialized in the production of adrenal steroids. The coordinate production of these steroids relies on adrenal cortex zonation, which corresponds to the establishment of distinct concentric functional zones in the perinatal perio...

AIMS To investigate the immunohisto-chemical staining of normal, hyperplastic, and neoplastic adrenal cortex with a monoclonal antibody against alpha inhibin. Also, to determine whether immunostaining with this antibody is useful in differentiating between adrenal cortical neoplasms and other tumours involving the adrenal gland that might mimic them. METHODS Normal adrenal tissue (n = 20) and...

INTRODUCTION Diagnosis of adrenal disease in domestic animals usually is dependent on the manipulation of the hypothalamo-pituitary-adrenal axis (HPA) and the measurement of cortisol (i.e., ACTH stim test; low dose dexamethasone suppression (LDDS) test; urine cortisol/creatinine ratio test; or the combined dexamethasone suppression/ACTH stimulation test). More recently, other steroid measuremen...

BACKGROUND Auto-immune adrenal insufficiency is a potentially fatal disorder. Young women with spontaneous premature ovarian failure (POF) are at increased risk of developing this condition. METHODS We further characterized auto-immune adrenal insufficiency in this population by conducting an in-depth cross-sectional evaluation of adrenal function in a series of 123 women. RESULTS We uncove...

Although the adrenal cortex and medulla arise from different embryological tissues, they are intimately associated in the developing embryo. The adrenal cortex arises from splanchnic mesenchyma, while the medulla arises from nervous tissue.' The chromaffin cells migrate by way of the celiac plexus to penetrate the adrenal cortex as scattered islands which later aggregate to form the adrenal med...

such factors in social evolution, but uncritical assertions, especially by so eminent a geneticist, serve only to confuse the issue. One aim of the authors, as expressed in the preface, is to "introduce the concepts and methods of genetics to the general student." Though the professional geneticist will find, as always in the work of Darlington and Mather, much food for thought, the general stu...

Steroid hormone biosynthesis by the fetal adrenal gland is crucial to the integrity and continuation of pregnancy, growth of the fetal and maternal tissues, as well as perinatal homeostatic adaptation for extrauterine survival. The adrenal cortex in the primate undergoes a remarkable morphological and functional remodeling such that the fetal adrenal cortex transforms into an adult adrenal cort...