The effects of chronic kidney disease on baroreflex control of renal sympathetic nerve activity (RSNA) and deficits in afferent and central components of the baroreflex were studied in juvenile and adult male Lewis Polycystic Kidney (LPK) and control Lewis rats under anesthesia (n=35). Blood pressure (BP), heart rate (HR), aortic depressor nerve activity (ADNA), and RSNA were determined after p...

MOTIVATION Ancient DNA (aDNA) molecules in fossilized bones and teeth, coprolites, sediments, mummified specimens and museum collections represent fantastic sources of information for evolutionary biologists, revealing the agents of past epidemics and the dynamics of past populations. However, the analysis of aDNA generally faces two major issues. Firstly, sequences consist of a mixture of endo...

Mycobacterial AdnAB exemplifies a family of heterodimeric motor-nucleases involved in processing DNA double strand breaks (DSBs). The AdnA and AdnB subunits are each composed of an N-terminal UvrD-like motor domain and a C-terminal RecB-like nuclease module. Here we conducted a biochemical characterization of the AdnAB motor, using a nuclease-inactivated heterodimer. AdnAB is a vigorous single ...

The ability to obtain ancient DNA (aDNA) from extinct species has greatly improved our study their evolutionary histories. Most aDNA studies focus on mitochondrial for both population-level and species-level insights, due its relatively high abundance increased obtainability. Although several approaches are available assemble mitogenomes, levels of damage non-target contaminating make many unsu...

Ancient DNA (aDNA) analysis is a powerful tool in multidisciplinary research on human remains, potentially leading to kinship scenarios and historical identifications. In this study, we present genetic investigation of three noble families from the 17th 19th centuries AD entombed burial crypts at cloister church Riesa (Germany). Tests were aimed identifying anticipated incidental relationships ...

Ancient DNA (aDNA) analyses from archaeological animal remains is well suited to many of the objectives investigated through zooarchaeological analyses. This paper aims at presenting field palaeogenomics, particularly in its application questions. While it does not seek for exhaustivity, focuses on practical issues, hoping promote trans-disciplinary dialogues. The authors begin with a presentat...

In Europe, the Middle Neolithic is characterized by an important diversification of cultures. In northeastern France, the appearance of the Michelsberg culture has been correlated with major cultural changes and interpreted as the result of the settlement of new groups originating from the Paris Basin. This cultural transition has been accompanied by the expansion of particular funerary practic...

Extinctions can dramatically reshape biological communities. As a case in point, ancient mass extinction events apparently facilitated dramatic new evolutionary radiations of surviving lineages. However, scientists have yet to fully understand the consequences of more recent biological upheaval, such as the megafaunal extinctions that occurred globally over the past 50 kyr. New Zealand was the ...

Ancient DNA (aDNA) is used to explore the genetic landscape of past and investigate movement, mixture, adaptation events that shaped present-day patterns human diversity. The present study was designed composition ancient people Sri Lanka. Despite low amino acid racemization often found in skeletal remains Lanka, we attempted extract from 5 individuals several sites intermediate climatic zone L...