some formulations of drug in adhesive transdermal drug delivery systems ()tddss)( with different functional and non-functional acrylic pressure sensitive adhesives psas)( were prepared. for this purpose fentanyl was used as a drug component. the effects of psas type on skin permeation and in vitro drug release from devices were evaluated using hydrodynamically well-characterized chien permeatio...

objective: leukocyte adhesion deficiency(lad) is a scarce, autosomal recessive inherited disorder . lad-i which is the most common type occurs due to mutations on the cd18 gene. this mutation leads to absence or severe reduction of leukocyte cell surface expression of ß2 integrin molecules which are necessary for the adhesion of the leukocytes to the endothelial cells, transendothelial migratio...

objective(s) staphylococcus aureus is a leading cause of many nosocomial and community acquired infections. according to many reports, antibiotic therapy can not guarantee the eradication of s. aureus infections. thus designing an adhesin based vaccine could restrain the s. aureus infections. this study designed for construction of a new fusion protein vaccine against s. aureus infections based...

conclusions the bacterial isolates exhibited strong biofilm formation potential, while the extracts of acacia arabica significantly inhibited biofilm formation among the isolates and, therefore, could be executed in the development of cost-effective biofilm inhibitor medicines. results pseudomonas aeruginosa (kc417303-05), staphylococcus hemolyticus (kc417306), and staphylococcus hominis (kc417...

background: endometriosis is defined as the growth of endometrial tissues in ectopic places outside the uterus. this disease has an important effect on the health and fertility of affected women. it’s etiology is not clearly known. for better understanding the pathophysiology of this disease, many researchers study on several aspects of the disease on animals. objective: in this experimental st...

Background: The immune-mediated responses in vascular cells may include the increased expression of endothelial adhesion molecules, leukocyte rolling and infiltration, cellular lipid dysregulation and vascular smooth muscle cells (VSMCs) differentiation. Investigating the cellular and molecular events involved in the rolling process is useful for treatment or prevention of the vessel stenosis es...

peritoneal adhesions are challenging in abdominal surgery. in spite of different kinds of treatments still no definitive and effective treatment is suggested. to determine the prevention effects of intraperitoneal (ip) methylene blue in post surgical adhesion formation 44 rabbits were randomly divided in two groups of equal number. group i received an intra peritoneal injection of a 1% suspensi...

inflammation of blood vessels is a characteristic feature of kawasaki disease. neutrophils play a key role in the inflammatory responses where movement of neutrophils toward the site of inflammation depends on cd11b/cd18 expression as adhesion molecules on these cells. the purpose of this study was to investigate cd11b/cd18 expression in patients with kawasaki disease upon diagnosis and after t...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background : adhesions, as abnormal scared tissue, are common following gynecological operations and can cause chronic pelvic pain, infertility, poor outcomes of future surgeries, and intestinal obstruction. oxygen free radicals are known as one of the main causes of adhesion formation. this study is to evaluate the effect...