Abstract Despite the remarkable outcome of immune checkpoint inhibitors (ICIs) in non-small cell lung cancer (NSCLC), a large number patients remain unresponsive to this therapy. A key factor unresponsiveness ICIs is intrinsic therapeutic resistance where monocytic myeloid-derived suppressor cells (M-MDSCs) contribute significantly via suppressing CD8 +T mediated anti-tumor response. Our result...

introduction: the role of adenosine a1 receptors of the amygdala on entorhinal cortex kindled seizures was investigated. material and methods: animals were kindled by daily electrical stimutation of entorhinal cortex. in the full kindled animals, n6-cyclohexyladenosine (cha 10, 50, 100, 500óm), an adenosine a1 receptor agonist and 8-cyclopentyl- 1, 3, dimethylxanthine (cpt, 10, 20 óm), an adeno...

Wolff-Parkinson-White (WPW) syndrome is caused by an accessory pathway that communicates between the atria and ventricles known as Bundle of Kent. The development atrial fibrillation, can result in impulses all being conducted via a sinister, board complex, irregular tachycardia, with varying QRS morphology (known pre-excited fibrillation) Adenosine potent atrioventricular node blocker, which b...

Although very common, the precise mechanisms that explain symptomatology of neuroendocrine syncope (NES) remain poorly understood. This disease, which can be incapacitating, manifests itself as a drop in blood pressure secondary to vasodilation and/or extreme slowing heart rate. As studies continue, involvement adenosinergic system is becoming increasingly evident. Adenosine, an ATP derivative,...

Adenosine, known as an endogenous neuroprotective agent and acting a cytoprotective modulator in organisms, is the subject of considerable scientific interest. Medicinal mushrooms represent good source bioactive compounds due to their composition potent adaptogenic action, affecting more than 300 biochemical processes functions organisms. The aim present study was investigate adenosine precurso...

Adenosine receptors that modulate adenylate cyclase activity have been identified recently in a number of tissues. The purpose of these investigations was to determine the effect of adenosine on ion transport in rabbit ileum in vitro. Adenosine and some of its analogues were found to increase the short circuit current (Isc) and the order of potency was N-ethylcarboxamide-adenosine 2 2-chloroade...

Continuous application of organic fertilizers can cause accumulation phosphorus (P) in soil, especially the low-molecular-weight (LMWOP) forms. This P pool represents a potentially important source for both plants and microorganisms. To understand effect long-term fertilization (30 years) (P-rich soil) vs. fallowing (P-poor on bioavailability fate LMWOP subtropical paddy soils, we determined so...