BACKGROUND Myocardial contractile response to beta1- and beta2-adrenergic receptor (AR) stimulation is severely impaired in chronic heart failure, in which G(i) signaling and the ratio of beta2/beta1 are often increased. Because beta2-AR but not beta1-AR couples to G(s) and G(i) with the G(i) coupling negating the G(s)-mediated contractile response, we determined whether the heart failure-assoc...

Background—Myocardial contractile response to 1and 2-adrenergic receptor (AR) stimulation is severely impaired in chronic heart failure, in which Gi signaling and the ratio of 2/ 1 are often increased. Because 2-AR but not 1-AR couples to Gs and Gi with the Gi coupling negating the Gs-mediated contractile response, we determined whether the heart failure–associated augmentation of Gi signaling ...

The phenomenon of adaptive response (AR) in animal and human cells exposed to ionizing radiation is well documented in scientific literature. We have examined whether such AR could be induced in mice exposed to non-ionizing radiofrequency fields (RF) used for wireless communications. Mice were pre-exposed to 900 MHz RF at 120 µW/cm(2) power density for 4 hours/day for 1, 3, 5, 7 and 14 days and...

Metastatic castration-resistant prostate cancer (mCRPC) shows a number of adaptive mechanisms that facilitate continued androgen receptor (AR) dependent tumor growth. In this article we reviewed the subsequent hormonal manipulation in mCRPC, including the recently approved new drugs, in relation to the AR dependent and independent growth mechanisms. Maintaining castrate levels of testosterone i...

OBJECTIVE Combination of β1-adrenergic receptor (AR) blockade and β2-AR activation might be a potential novel therapy for treating heart failure. However, use of β-AR agonists and/or antagonists in the clinical setting is controversial because of the lack of information on cardiac inotropic or chronotropic regulation by AR signaling. METHODS In this study, we performed hemodynamic evaluation ...

Dynamic linear regression models are used widely in applied econometric research. Most applications employ autoregressive (AR) models, distributed lag (DL) or (ARDL) models. These however, perform poorly for data sets with unknown, complex nonlinear patterns. This paper studies and semiparametric extensions of the dynamic model explores two techniques to allow unknown forms nonlinearities funct...

In this paper, the enhancement of vehicle stability and handling is investigated by control of the active geometry suspension system (AGS). This system could be changed through control of suspension mounting point’s position in the perpendicular direction to wishbone therefore the dynamic is alternative and characteristics need to change. For this purpose, suitable controller needs to change...

PURPOSE To assess the changes in the accommodative response of the eye while reading a text under different contrast polarity conditions: black letters on white background (BoW condition) and white letters on black background (WoB condition). METHODS Eighteen subjects with ages ranging from 21 to 41 years participated in this experimental study. The accommodative response (AR) of the eye whil...

The development of lethal, castration resistant prostate cancer is associated with adaptive changes to the androgen receptor (AR), including the emergence of mutant receptors and truncated, constitutively active AR variants. AR relies on the molecular chaperone HSP90 for its function in both normal and malignant prostate cells, but the requirement for HSP90 in environments with aberrant AR expr...

With the advent of packetized audio transmission, such as voice over IP (VoIP), and Voice over WLAN (VoWLAN), echo cancellation has put forth many challenging requirements. When an adaptive filter echo cancellation algorithm is used, its performance can be greatly increased, and its complexity can be reduced if it is only applied to the active regions in which echo exists. The proposed scheme e...