Thrombocytopenia 2 (THC2), a non-syndromic, autosomal dominant thrombocytopenia, is caused by mutations in the ANKRD26 gene, located on chromosome 10p12. Thus far, 12 heterozygous single nucleotide substitutions in the 5′-untranslated region of the ANKRD26 gene have been described in 21 families. Affected patients usually present with moderate thrombocytopenia with normal platelet size and norm...

Mild anemia and leukopenia are the most common hematologic problems of acute brucellosis. Mild thrombocytopenia also occurs, but severe cases are uncommon. Thrombocytopenia occurs because of bone marrow suppression, hypersplenisem, hemophagocytosis, and immunologic destruction of the cells or disseminated intravascular coagulation. In endemic areas, hemorrhagic fevers, hematologic malignancies,...

BACKGROUND The development of thrombocytopenia in acute coronary syndromes (ACS) appears to be associated with adverse clinical outcomes. Unfractionated heparin is a recognized cause of thrombocytopenia, but the incidence, predictors, and prognostic significance of thrombocytopenia during hirudin therapy in ACS have not been reported. METHODS AND RESULTS Patients with ACS without ST elevation...

Ticagrelor is a new oral antiplatelet drug that has a strong proven benefit of reducing the rate of death from cardiovascular causes, myocardial infarction, and stroke compared with clopidogrel. Ticagrelor is widely used by patients with acute coronary syndrome. However, profound thrombocytopenia has never been previously reported in such patients. We herein present our experience with a case o...

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease in China. The incidence and clinical and laboratory characteristics of SFTS are not clearly defined. During May 22-October 2, 2011, a total of 24 patients with fever, thrombocytopenia, and leukopenia were clinically diagnosed as having SFTS in Yiyuan County, Shandong Province, China. We conducted laboratory tes...

ABSTRACT
 Malaria is a tropical infectious disease with high morbidity and mortality rates. In malaria, various kinds of haematological complications can arise, one which thrombocytopenia. Thrombocytopenia most commonly encountered during acute malaria infection varying degrees observed in both Plasmodium falciparum vivax infections. The purpose this study was to determine the relationship...

Hematological disorders due to covid 19 infection are increasingly known hyperleukocytosis, lymphopenia and thrombocytopenia. However, the association between non-existent, non-apparent or asymptomatic acute leukemia remains rare. No causal relationship has been established leukemia. We report a case of young patient admitted for treatment severe viral pneumonitis in whom an was diagnosed.

674 Acute thrombocytopenias are common clinical problems of diverse etiologies and paradoxically, some of the most dramatic forms are iatrogenic in nature (1). For example, drugs that are given to patients to treat or prevent arterial or venous thrombosis (such as heparin, abciximab, and other agents that block the platelet integrin receptor αIIbβ3) can cause immune reactions that lead to life-...

Background: Spontaneous heparin-induced thrombocytopenia is a pro-thrombotic syndrome in which anti-heparin antibodies develop without heparin exposure. Case presentation: A 78-year-old man who underwent successful lumbar laminectomy presented to the hospital 5 days after discharge for stroke-like symptoms and was found have acute infarcts of bilateral frontal lobes. The patient be severely thr...