introduction: it is known that acute and chronic stress induce hormonal and neuronal changes which affecting both pain threshold and nociceptive behaviours. orexin plays an important role in modulation of pain and stress. considering pain modulation during stress and the role of orexin in pain and stress, orexin might be involved in pain modulation during stress.we evaluated the involvement of ...

background: acute low back pain is one of the most prevalent diseases which more than 90% of the adults experience at least once during lifetime. the present study was conducted to determine the efficacy of duration of hot water bag usageon pain relief in in the patients with acute low back pain. methods: this clinical trial study was conducted on 20- to 50-year-old patients referring orthopedi...

background: excess amounts of lead in serum may affect different organ systems and cause lead poisoning. this toxicity mostly happens in chronic and occupational settings. this report comprises the clinical presentation of an acute case of lead toxicity with a much uncommon source of poisoning: opium. case presentation: a 25 year old man was presented to us with abdominal pain, nausea and vomit...

Abstract Metastatic bone tumor-induced changes in gene transcription and translation in pain-related regions of the nervous system may participate in the development and maintenance of bone cancer pain. Epigenetic modifications including DNA methylation regulate gene transcription. Here, we report that intrathecal injection of decitabine, a DNA methyltransferase (DNMT) inhibitor, dose dependent...

Fibrodysplasia ossificans progressiva (FOP) is an autosomal dominant genetic transmitted disease, with a rare incidence (1-2 cases/million persons) and it usually affects female patients. Its manifestations include acute pain episodes that tend to repeat, involving the soft tissue and the axial muscles with later appearance of ectopic bone tissue in ligaments, joints and tendons. In the great m...

OBJECTIVE The purpose of this study was to analyze the relationship between fracture pattern and the development of acute radiculopathy after osteoporotic lumbar compression fracture. METHODS This study included 59 patients who underwent bone cement augmentation for osteoporotic compression fracture below the L2 level, which can lead to radiculopathic radiating pain. The patients were divided...

PURPOSE Most surviving pediatric osteosarcoma patients experience osteoporosis, bone pain, and pathologic fracture during and after therapy. The aim of this study was to evaluate the efficacy and side effects of pamidronate therapy in these patients. METHODS Nine osteosarcoma patients (12.8±1.6 years of age; 5 boys and 4 girls) who had a history of nontraumatic fracture or severe pain after c...

AIM (1) To describe a process approach to the improvement of pain management in emergency departments. (2) To compare analgesia ordering and administration practices for patients with acute fractures before and after implementation of a nurse managed, titrated intravenous narcotic policy. METHOD Retrospective chart review of patients with long bone fractures for the years 1993 and 1997. RES...

Case presentation: O.R, male, 2 years and 6 months, language social delay. The diet was based on bread, rice, beans yogurt. Petechiae gingival bleeding were noted 55 days ago. After 15 days, progressive pain in the lower limbs prevented child to sit or walk. clinical examination showed edema, pseudofolliculitis, petechiae intense palpation mobilization of limbs, spots hypertrophy gingivae. Bloo...

introduction gradenigo’s syndrome consists of ophthalmoplegia, facial palsy, and facial pain due to involvement of abducens and facial nerves as well as the trigeminal ganglion. this involvement is due to infections of ipsilateral middle ear and mastoid bone. case presentation a 14-month-old girl was referred to a private clinic with chief complaint of acute and sudden-onset right ophthalmopleg...