نتایج جستجو برای: active site concentration
تعداد نتایج: 1100816 فیلتر نتایج به سال:
1. The authors use a polyexponential equation (equation 1) to describe the time course of the plasma concentrations of a drug in lieu of a compartmental interpretation suggested by Sheiner et al. As a consequence, the effect compartment can now contain any amount of a drug and is not limited to being “negligibly small” as postulated by Sheiner et al. 2. Sheiner et al. introduced keo as the firs...
background: tubulin protein being the fundamental unit of microtubules is actively involved in cell division thus making them a potential anti-cancer drug target. in spite of many reported drugs against tubulin, few of them have started developing resistance in human β-tubulin due to amino acid substitutions. methods: in this study we generated three mutants (f270v, a364t and q292e) using model...
HCV-induced hepatitis is one of the most debilitating diseases. The limited number of anti-HCV drugs and drug-resistance necessitate developing of new scaffolds with different mode of actions. HCV non-structural protein 5B (NS5B) is an attractive target for development of novel inhibitors of HCV replication. In this paper, new N'-arylidene-6-(benzyloxy)-4-oxo-1,4-dihydroquinoline-3-carbohydrazi...
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