Background: Chemokines are a family of cytokines initially characterized by their capacity to induce chemotaxis, or directed leukocyte migrations. These receptors are activated by chemotactic cytokines called chemokines. Interactions between chemokines and chemokine receptors also are involved in tumorigenesis, migration and invasion of lymphoma cells.Methods: An English literature search...

Complement peptide receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on [113]) are activated endogenous ~75 amino-acid anaphylatoxin polypeptides C3a and C5a, generated upon stimulation of complement cascade. C5a exert their functions through binding to (C3a receptor, receptor 1 2), causing cell recruitment triggering cellular degranulation that contributes local inflammation.

it has been shown that activated t-cells produce and release both il-2 and il- 2 receptors (ll-2r). the rate of il-2 release is proportional to its cell surface expression and state of cell activation. to clarify the molecular basis of this immunological aberration, we analysed the amount of soluble il-2r(sil2-r) by an elisa technique in 68 patients with behcet's disease (bd), 28 patient c...

Natural killer (NK) cells are specialized lymphocytes primarily involved in the response to infection and tumors. NK characterized by presence of specific surface molecules, as well a wide repertoire receptors that impart microenvironment‑dependent effector functions. Among these receptors, Toll‑like (TLRs) can be activated condition either cytotoxic or immunoregulatory phenotype. However, cell...

The 2TM domain family of K channels are also known as the inward-rectifier channel family. This includes strong (Kir2.x) that constitutively active, G-protein-activated (Kir3.x) and ATP-sensitive (Kir6.x, which combine with sulphonylurea receptors (SUR1-3)). pore-forming α subunits form tetramers, heteromeric may be formed within subfamilies (e.g. Kir3.2 Kir3.3).

g -aminobutiric acid (gaba), the major inhibitory neurotransmitter in the central nervous system has two major receptor subtypes (gabaa and gabab). gabab receptors are activated by the antispastic and muscle relaxant agent, baclofen, which is a lipophilic derivative of gaba. since 1962 several strategies have been reported for the synthesis of baclofen.in this study an approach has been made to...