نتایج جستجو برای: acid sensing ion channel 1a

تعداد نتایج: 1253447  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Matthew W Coryell Amanda M Wunsch Jill M Haenfler Jason E Allen Mikael Schnizler Adam E Ziemann Melloni N Cook Jonathan P Dunning Margaret P Price Jon D Rainier Zhuqing Liu Alan R Light Douglas R Langbehn John A Wemmie

No animal models replicate the complexity of human depression. However, a number of behavioral tests in rodents are sensitive to antidepressants and may thus tap important underlying biological factors. Such models may also offer the best opportunity to discover novel treatments. Here, we used several of these models to test the hypothesis that the acid-sensing ion channel-1a (ASIC1a) might be ...

2016
Feng Yang Xiaolong Sun Yinxiu Ding Hui Ma Tangpeng Ou Yang Yue Ma Dong Wei Wen Li Tianle Xu Wen Jiang

Unraveling mechanisms underlying epileptogenesis after brain injury is an unmet medical challenge. Although histopathological studies have revealed that reactive astrogliosis and tissue acidosis are prominent features in epileptogenic foci, their roles in epileptogenesis remain unclear. Here, we explored whether astrocytic acid-sensing ion channel-1a (ASIC1a) contributes to the development of c...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Lan Jing Xiang-Ping Chu Yu-Qing Jiang Daniel M Collier Bin Wang Qian Jiang Peter M Snyder Xiang-Ming Zha

Acid-sensing ion channel-1a (ASIC1a) is a potential therapeutic target for multiple neurological diseases. We studied here ASIC1a glycosylation and trafficking, two poorly understood processes pivotal in determining the functional outcome of an ion channel. We found that most ASIC1a in the mouse brain was fully glycosylated. Inhibiting glycosylation with tunicamycin reduced ASIC1a surface traff...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Tudor Bartoi Katrin Augustinowski Georg Polleichtner Stefan Gründer Maximilian H Ulbrich

Acid-sensing ion channels (ASICs) are widely expressed proton-gated Na(+) channels playing a role in tissue acidosis and pain. A trimeric composition of ASICs has been suggested by crystallization. Upon coexpression of ASIC1a and ASIC2a in Xenopus oocytes, we observed the formation of heteromers and their coexistence with homomers by electrophysiology, but could not determine whether heteromeri...

2016
Leah R. Reznikov David K. Meyerholz Ryan J. Adam Mahmoud Abou Alaiwa Omar Jaffer Andrew S. Michalski Linda S. Powers Margaret P. Price David A. Stoltz Michael J. Welsh

Neurons innervating the airways contribute to airway hyperreactivity (AHR), a hallmark feature of asthma. Several observations suggested that acid-sensing ion channels (ASICs), neuronal cation channels activated by protons, might contribute to AHR. For example, ASICs are found in vagal sensory neurons that innervate airways, and asthmatic airways can become acidic. Moreover, airway acidificatio...

Journal: :The Journal of biological chemistry 2011
Lindsey A Tolino Sora Okumura Ossama B Kashlan Marcelo D Carattino

Acid-sensing ion channels (ASICs) are trimeric cation channels that undergo activation and desensitization in response to extracellular acidification. The underlying mechanism coupling proton binding in the extracellular region to pore gating is unknown. Here we probed the reactivity toward methanethiosulfonate (MTS) reagents of channels with cysteine-substituted residues in the outer vestibule...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
Mohammed Ettaiche Emmanuel Deval Marc Cougnon Michel Lazdunski Nicolas Voilley

The action of extracellular protons on retinal activity and phototransduction occurs through pH-sensitive elements, mainly membrane conductances present on the different cell types of the outer and inner nuclear layers and of the ganglion cell layer. Acid-sensing ion channels (ASICs) are depolarizing conductances that are directly activated by protons. We investigated the participation of ASIC1...

Journal: :Scientific reports 2016
Ming-Gang Liu Hu-Song Li Wei-Guang Li Yan-Jiao Wu Shi-Ning Deng Chen Huang Oleksandr Maximyuk Volodymyr Sukach Oleg Krishtal Michael X Zhu Tian-Le Xu

The exact roles of acid-sensing ion channels (ASICs) in synaptic plasticity remain elusive. Here, we address the contribution of ASIC1a to five forms of synaptic plasticity in the mouse hippocampus using an in vitro multi-electrode array recording system. We found that genetic deletion or pharmacological blockade of ASIC1a greatly reduced, but did not fully abolish, the probability of long-term...

Journal: :The Journal of biological chemistry 2010
Nobuyoshi Kusama Anne Marie S Harding Christopher J Benson

Acid-sensing ion channels (ASICs) are sodium channels gated by extracellular protons. The recent crystallization of ASIC1a identified potential binding sites for Cl(-) in the extracellular domain that are highly conserved between ASIC isoforms. However, the significance of Cl(-) binding is unknown. We investigated the effect of Cl(-) substitution on heterologously expressed ASIC1a current and H...

Journal: :Annals of surgery 2011
Rong Hu Bo Duan Dianshi Wang Ye Yu Weiguang Li Haishui Luo Peigang Lu Jiangkai Lin Gang Zhu Qi Wan Hua Feng

OBJECTIVE To determine the cellular and molecular mechanisms by which acid-sensing ion channel 1a (ASIC1a) plays its role in the secondary injury after traumatic spinal cord injury (SCI), and validate the neuroprotective effect of ASIC1a suppression in SCI model in vivo. BACKGROUND Secondary damage after traumatic SCI contributes to the exacerbation of cellular insult and thereby contributes ...

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