Our aim was to simultaneously investigate 2 techniques for in vivo sampling of peripheral compartment pharmacokinetics after systemic administration of acetylsalicylic acid. Ten volunteers were given 2 g acetylsalicylic acid orally. Blood samples and dialysates from 4 microdialysis probes inserted in the dermis of the forearm were collected for 5 h and suction blisters were raised 1-3 h after d...

In this work agar- and borax-based hydrogels with without the addition of poly(vinyl alcohol) (PVA) at different concentrations were synthesized. Hydrogels modified by same amount acetylsalicylic acid (ASA) which exhibits antithrombotic properties. The effect modification ASA on properties was analyzed.

The potential interaction between acetylsalicylic acid and angiotensin-converting enzyme inhibitors in patients with heart failure has received considerable attention lately. Opposing effects on prostaglandin synthesis and metabolism form the theoretical basis of an interaction. A review of the available literature revealed conflicting data from animal studies, human pharmacological studies, an...