Background Poly cystic ovarian syndrome (PCOS) is the most prevalent endocrinopathy among women and the most common underlying diagnosis for anovulatory infertility. The role of insulin-resistance (IR) and hyperinsulinemia in pathophysiology and clinical manifestations of the syndrome depicts the importance of evaluation of the efficacy of insulin reducing medications. N acetyl cysteine (NAC) i...

Background: Poly cystic ovarian syndrome (PCOS) is the most prevalent endocrinopathy among women and the most common underlying diagnosis for anovulatory infertility. The role of insulin-resistance (IR) and hyperinsulinemia in pathophysiology and clinical manifestations of the syndrome depicts the importance of evaluation of the efficacy of insulin reducing medications. N acetyl cysteine (NAC) ...

Cysteine is the major source of fixed sulfur for the synthesis of sulfur-containing compounds in organisms of the Bacteria and Eucarya domains. Though pathways for cysteine biosynthesis have been established for both of these domains, it is unknown how the Archaea fix sulfur or synthesize cysteine. None of the four archaeal genomes sequenced to date contain open reading frames with identities t...

A new isoform of human manganese superoxide dismutase (SOD) has been recently isolated and obtained in a synthetic recombinant form termed rMnSOD. As compared to other SODs, this exhibits dramatically improved cellular uptake an intense antioxidant antitumoral activity. Unfortunately, its use is severely hampered as active pharmaceutical ingredient (API) solution suffers from remarkable instabi...

This study investigated the effects of pectin, chitosan, sodium alginate, and carboxymethyl cellulose-based edible coatings, individually and/or in combination with N-acetyl cysteine as an antibrowning agent, on some physical, chemical, antioxidant properties white button mushrooms. The weight loss, color change, browning index, degree cap opening, soluble solid content, total phenolic activity...

background: poly cystic ovarian syndrome (pcos) is the most prevalent endocrinopathy among women and the most common underlying diagnosis for anovulatory infertility. the role of insulin-resistance (ir) and hyperinsulinemia in pathophysiology and clinical manifestations of the syndrome depicts the importance of evaluation of the efficacy of insulin reducing medications. n acetyl cysteine (nac) ...

Simultaneous separation of 37 proteinogenic D/L-amino acids excluding proline with HPLC is generally difficult. In this study, two sets o-phthalaldehyde (OPA)-based fluorescent diastereomers were formed using chiral thiols N-acetyl-L-cysteine (NAC) and N-isobutyryl-L-cysteine (NIBC) independently. It expected that obtained OPA-derivatized D/L show different retention selectivity in reversed pha...

PURPOSE To investigate the effects of copaiba oil on the hepatic damage induced by paracetamol. METHODS Thirty six rats were distributed into six study groups (N=6): control group, that didn't receive the acetaminophen; Acetaminophen Group, that only received the acetaminophen; Prophylactic Copaiba Group 1, that received copaiba oil two hours before the acetaminophen; Prophylactic Copaiba Gro...

The mechanism of acyl enzyme formation from acylCoA derivatives was studied for chicken liver fatty acid synthase in 0.1 M potassium phosphate (pH 7.0) and 1 mM EDTA at 23 OC. Three mechanistically important acyl-binding sites exist: a cysteine, 4‘-phosphopantetheine, and a hydroxyl (serine). The cysteine was specifically labeled with iodoacetamide, and chemical modification of this labeled enz...