Acetone is being proposed as the main washing solvent during automated synthesis of oligonucleotides to reduce acetonitrile usage in the assembly process and endure the impact of global acetonitrile shortage.

The title compound, C(12)H(8)BrN, was prepared as a starting material for a Suzuki cross-coupling reaction with a pinacol ester. The torsion angle about the ring-methylene C-C bond is 30.7 (3)°, such that the N atom is displaced by 1.174 (4) Å from the plane of the naphthalene ring system.

In the title compound, C(9)H(9)NO(2)S, the benzene ring and the acetonitrile group are approximately coplanar, with a C-C-C-C torsion angle of 1.1 (3)° between them. In the crystal, mol-ecules are linked via inter-molecular C-H⋯O hydrogen bonds into layers parallel to (001).

The adsorption of the proton-pump inhibitor omeprazole was investigated using RP-LC with chemometric models combined with adsorption isotherm modelling to study the effect of pH and type of organic modifier (i.e., acetonitrile or methanol). The chemometric approach revealed that omeprazole was tailing with methanol and fronting with acetonitrile along with increased fronting at higher pH. The i...

The evaluation of extraction protocols for untargeted metabolomics approaches is still difficult. We have applied a novel stable isotope-assisted workflow for untargeted LC-HRMS-based plant metabolomics , which allows for the first time every detected feature to be considered for method evaluation. The efficiency and complementarity of commonly used extraction solvents, namely 1 + 3 (v/v) mixtu...

Acetonitrile is commonly used as an organic solvent and can also be important intermediate in synthesis. Its widespread use has led to the development of new methods for synthesis a variety compounds. In past decades, conversion reactions acetonitrile building block have become one most-attractive fields Especially field electrochemical conversions involving acetonitrile, due its good conductiv...

The performance of three hydrophobic carboxylic acid based Deep Eutectic Solvents were evaluated for the extraction 1-butanol and acetonitrile from aqueous solution. To do so, phase diagrams five ternary systems {[DL-menthol: lauric acid] + water 1-butanol}, capric acetonitrile}, {[TBAMBr:capric 1-butanol} {[TBAMBr: measured at 298.15 K atmospheric pressure. Liquid-liquid equilibria data used t...

Introduction Conclusions References

A simple, selective and precise stabilityindicating HPLC method for determination of glabridin diacetate and dihexanoate prodrugs was developed, validated and applied to the enzymatic and chemical hydrolysis studies. The chromatographic separation was achieved on a reverse phase C18 (Thermo Hypersil-Keystone, 250 × 4.6 mm, 5 micron) column using the mixture of acetonitrile and water as mobile p...

Acetonitrile is a choice of solvent for almost all chromatographic separations. In recent years, researchers around the globe have faced an acetonitrile shortage that affected routine analytical operations. Researchers have tried to counter this shortage by applying many innovative solutions, including using ultra performance liquid chromatography (UPLC) columns that are shorter and smaller in ...