Sixteen new phthalimide derivatives were synthesized and evaluated for their in vitro anti-microbial, anti-oxidant and anti-inflammatory activities. The cytotoxicity for all synthesized compounds was also determined in cancer cell lines and in normal human cells. None of the target derivatives had any cytotoxic activity. (ZE)-2-[4-(1-Hydrazono-ethyl) phenyl]isoindoline-1,3-dione (12) showed rem...

Treatment of 3-formylacetylacetone with the amines benzylamine, tert -butylamine and ( S )-methylbenzylamine led to formation corresponding Schiff bases 3-[(benzylamino)methylidene]pentane-2,4-dione, C 13 H 15 NO 2 1 ), 3-[( -butylamino)methylidene]pentan-2,4-dione, 10 17 ) 3-{[( )-benzyl(methyl)amino]methylidene}pentane-2,4-dione, 14 3 ). The molecules all three compounds exist as enamine taut...

The mol-ecule of the title compound, C(18)H(12)N(2)O(4), is situated on a crystallographic centre of symmetry. The mol-ecule has a zigzag structure, with two parallel symmetry-related indoline-2,3-dione fragments linked by an ethyl-ene group at each N atom. In the crystal, the mol-ecules stack in columns along the b axis. There are two such columns in the structure. The mol-ecules within each c...

In the title compound, C(14)H(10)O(2), the acenaphthene-quinone core is essentially planar, with an r.m.s. deviation of 0.0140 Å. In the crystal, mol-ecules are connected by π-π stacking inter-actions [centroid-centroid distances = 3.766 (3), 3.839 (3) and 3.857 (3) Å], forming columns parallel to the a axis.

Two polypyridyl copper(II) complexes, [Cu(phen)(phen-dione)Cl]Cl (1) and [Cu(bpy) (phen-dione)Cl]Cl (2), (where Phen =1,10-phenanthroline, bpy =2,2'-bipyridine and Phen-dione = 1,10-phenanthroline-5,6-dione), were used as efficient catalysts for the oxidation of benzyl alcohol to benzaldehyde. The effects of various parameters such as reaction temperature, reaction time, etc. were studied. The ...

Metabolic activation of the proximate carcinogen benzo[a]pyrene-7,8-trans-dihydrodiol (B[a]P-7,8-trans-dihydrodiol) by aldo-keto reductases (AKRs) leads to B[a]P-7,8-dione that is both electrophilic and redox-active. B[a]P-7,8-dione generates reactive oxygen species resulting in oxidative DNA damage in human lung cells. However, information on the formation of stable B[a]P-7,8-dione-DNA adducts...

Brønsted acidic ionic liquid triethylamine-bonded sulfonic acid {[Et3N-SO3H]Cl} efficiently catalyzes the one-pot multi-component condensation of 2-naphthol with arylaldehydes and dimedone (5,5-dimethylcyclohexane-1,3-dione) under solvent-free conditions to afford 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-ones in high yields and relatively short reaction times.

Phytochemical profiling was undertaken on the crude extracts of Drosera magna to determine nature chemical constituents present. In total, three new flavonol diglycosides (1–3), one flavan-3-ol glycoside (4), and 12 previously reported compounds (5, 9), (15), flavanone (8), 1,4-napthoquinone (6, 7, 13, 14), 2,3-dehydroxynapthalene-1,4-dione (10–12), phenolic acid (16) structure classes were iso...