These confirmatory reports have verified all the essential features of the disease that was first described. Mucosal ulceration in the form of intractable stomatitis is the most constant clinical feature of the disease. In no case to-date has this been absent. Cutaneous manifestations including blisters, lichenoid eruption or erythema multiforme like lesions are highly variable. These can chang...

Pemphigus vulgaris is a chronic, life-altering bullous autoimmune disease with production of antibodies against the desmosomal proteins Desmogleins 3 and 1 (Dsg) causing acantholysis. Ubiquitous antibody deposition but discontinuous manifestation indicate possible role cofactors. In this study, we focus on FasL as putative cofactor in PV-related To study cell-death dependent processes during PV...

INTRODUCTION Paraneoplastic pemphigus is an autoimmune disease associated with an underlying tumor. Several cases have been reported as unusual pemphigus vulgaris, erythema multiforme, or paraneoplastic bullous disease, but the incidence of the condition is unknown. Response to treatment is generally poor, with significant morbidity and mortality. This condition is clinically characterized by s...

Varicella (chickenpox) is a highly contagious disease caused by varicella zoster virus (VZV). The primary infection results in acute varicella with fever, malaise, and a widely disseminated vesicular and itching rash, frequently solving with scars. The rash begins on the face, scalp, and trunk and occurs in crops; typically, lesions are at different stages of evolution. The oral mucous membrane...

Darier disease is an autosomal-dominant inherited condition caused by mutation of a gene, which produces a protein involved in calcium channel regulation. The disease has a variety of manifestations and lacks consistent genotype-phenotype correlations. Acral hemorrhagic Darier disease causes macules, papules, vesicles and/or hemorrhagic blisters on the extremities. Other classic signs of the di...

Warty (follicular) dyskeratoma (WD) is a discrete nodular lesion that demonstrates the characteristic histopathologic findings of acantholysis and dyskeratosis. WDs most commonly occur on the head and neck of adults. We present a case of WD that occurred on the mons pubis of a 53-year-old woman. Only a few other cases of WDs occurring on the vulva have been reported. WD most likely represents a...