BACKGROUND Recent studies from Australia, New Zealand, and Sweden have reported declines in abdominal aortic aneurysm (AAA) incidence, prevalence, and mortality. This finding may have important implications for screening programs. This study determined trends in AAA incidence and mortality in England and Wales. METHODS AND RESULTS Cause-specific mortality data for England and Wales were obtai...

Although anti-drug antibodies against biologics have been associated with decreased clinical efficacy, the immunogenicity of biologics seems to vary between drugs, diseases and ethnicities. This study aims to investigate the predictors for the formation of anti-adalimumab antibodies (AAA) and the clinical consequences of AAA formation. In 53 Chinese psoriatic patients treated with adalimumab, A...

This memo proposes an Authentication, Authorization, Accounting (AAA) architecture that would incorporate a generic AAA server along with an application interface to a set of Application Specific Modules that could perform application specific AAA functions. A separation of AAA functions required in a multi-domain environment is then proposed using a layered protocol abstraction. The long term ...

OBJECTIVE Acquiring contemporary data on prevalence and natural history of abdominal aortic aneurysms (AAA) is essential in the effort to optimise modern screening programmes. The primary aim of this study was to determine the fate of a 65-year-old male population 5 years following an invitation to an aortic ultrasound (US) examination. METHODS In this population-based cohort-study, men were ...

The pathogenesis of abdominal aortic aneurysm (AAA) is characterized to be inflammation-associated degeneration of vascular wall. Neovascularization is regularly found in human AAA and considered to play critical roles in the development and rupture of AAA. However, little is known about lymphangiogenesis in AAA. The purpose of this study was to demonstrate both angiogenesis and lymphangiogenes...

PURPOSE We present extended follow-up findings of the Kingston prospective sizing program for patients with abdominal aortic aneurysm (AAA) smaller than 5.0 cm in diameter, with gender-specific analysis. METHODS From 1976 to 2001, 895 patients (688 men, 207 women) with AAA smaller than 5.0 cm were entered, regardless of fitness, in a prospective sizing program in which computed tomography sca...

Background An abdominal aortic aneurysm (AAA) is a progressive, generally symptomless disease that could ultimately result in a fatal rupture. Current guidelines advise conservative follow-up, and preventive surgical repair once the risk of rupture outweighs the cost of repair (55 mm in men). In developed countries, the majority of patients are diagnosed with AAAs less than 55 mm, and so enter ...

T he modern open surgical management of abdominal aortic aneurysm (AAA) has changed little since its inception in the 1950s. Endoaneurysmorrhaphy, first described by Rudolph Matas in 1888, involved ligating the branches of an aneurysm from within the aneurysm sac. Approximately 25 years later at the beginning of the 20th century, Alexis Carrel received the Nobel Prize for demonstrating the feas...

A literature review was performed using Medline, PubMed, Web of Science, and The Cochrane Library databases from inception to August 2020. Ten randomized controlled trials with 2045 participants an asymptomatic abdominal aortic aneurysm (AAA) follow-up ∼1.5 5 years were analyzed. Neither blood pressure-lowering medications nor antibiotics reduced AAA-related events or AAA growth. This meta-anal...