Melanoma is often caused by mutations due to exposure to ultraviolet radiation. This study reports a recurrent somatic C > T change causing a P131L mutation in the RQCD1 (Required for Cell Differentiation1 Homolog) gene identified through whole exome sequencing of 20 metastatic melanomas. Screening in 715 additional primary melanomas revealed a prevalence of ~4%. This represents the first repor...

Aβ42 peptide binds neuronal membranes and aggregates into plaques that are characteristic of Alzheimer's disease. has been proposed to be generated in membrane (nano) domains the liquid-ordered phase, ganglioside GM1 being a major facilitator binding membrane. The exists solution various degrees aggregation, either monomers, oligomers or fibrils, which appear particularly toxic. present study r...

Introduction: Many molecules can be labeled by iodine. Some of labeled substances are used for investigations of cancer treatment, biodistribution study in body, receptor binding, secrete pathway etc. Peptides are biomolecules and can be labeled by 131Iodine. ICD- 85 is a tri-peptide derived from Iranian brown snake venom and scorpion venom. This tri-peptide treats cancer by i...

Recently, antimicrobial peptides have been introduced as potent antibiotics with a wide rangeof antimicrobial activities. They have also exhibited other biological activities, including antiinflammatory,growth stimulating, and anti-cancer activities. In this study, an analog of MagaininII was designed and produced as a recombinant fusion protein. The designed sequence containe...

Human leukocyte antigen (HLA) can recognize and bind foreign peptides to present them specialized immune cells, then initiate an response. Computational prediction of the peptide HLA (pHLA) binding speed up immunogenic screening facilitate vaccine design. However, there is a lack automatic program optimize mutated with higher affinity target allele. Here, fill this gap, we develop TransMut fram...

The in silico modelling of peptides complementary to lactoferrin was carried out using the Protein 3D software package and replication natural bonding site between pneumococcal surface protein (PSP) (LF). modeling based on analysis conjugated ion–hydrogen bond systems these proteins (CIHBS). oligopeptide EEVAPQAQAKIAELENQVHRLE proposed via computer synthesized solid phase synthesis technique, p...

Conventional photoredox catalytic additions of alcohols to olefins require additives, like thiophenol, promote back electron transfer. The concept “photozymes” assumes that forward and backward transfer steps in a cycle are controllable by substrate binding photocatalytically active peptides. Accordingly, we synthesized short tripeptide modified with 1,7-dicyano-perylene-3,4 : 9,10-tetracarboxy...

The identification of the mechanisms by which T-cell receptors (TCRs) interact with human antigens provides a crucial opportunity to develop new vaccines, diagnostics and immunotherapies. However, accurate prediction recognition TCR–antigen pairing represents substantial computational challenge in immunology. Existing tools only learn binding patterns from many known TCR repertoires fail recogn...