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In focal hand dystonia, the cortical somatosensory representation of the fingers is abnormal, with overlapping receptive fields and reduced interdigit separation. These abnormalities are associated with deficits in sensory perception, as previously demonstrated by applying tactile stimuli to one finger at a time. What is still unknown is whether the sensory deficits can be observed when tactile...
Genome-wide association studies are set to become the method of choice for uncovering the genetic basis of human diseases. A central challenge in this area is the development of powerful multipoint methods that can detect causal variants that have not been directly genotyped. We propose a coherent analysis framework that treats the problem as one involving missing or uncertain genotypes. Centra...
D Rapid eye movement sleep is maximal during early life, but its function in the developing brain is unknown. We investigated the role of rapid eyemovement sleep in a canonicalmodel of developmental plasticity in vivo (ocular dominance plasticity in the cat) induced by monocular deprivation. Preventing rapid eye movement sleep after monocular deprivation reduced ocular dominance plasticity and ...
Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D)1–11. Established associations to common and rare variants explain only a small proportion of the heritability of T2D. As previously published analyses had limited power to identify variants with modest effects, we carried out meta-analysi...
REPORT Autonomic dysfunction is a major feature of cerebellar ataxia, neuropathy, vestibular areflexia ‘CANVAS’ syndrome Teddy Y. Wu, Jennifer M. Taylor, Dean H. Kilfoyle, Andrew D. Smith, Ben J. McGuinness, Mark P. Simpson, Elizabeth B. Walker, Peter S. Bergin, James C. Cleland, David O. Hutchinson, Neil E. Anderson, Barry J. Snow, Tim J. Anderson, Laura A.F. Paermentier, Nick J. Cutfield, And...
‘Proto-industrialization’ is the name given to the massive expansion of exportoriented handicrafts which took place in many parts of Europe between the 16th and the 19th centuries. An influential theory holds that these proto-industries generated the capital, labour, entrepreneurship, agricultural commercialization, and consumer demand needed for factory industrialization. Protoindustrializatio...
Methods and Results-—Using the local Get with the Guidelines-Stroke registry, we analyzed 4305 consecutively admitted ischemic stroke patients (March 2002–December 2011). The sample was divided into smokers versus nonsmokers. The main outcome of interest was the overall inpatient mortality. Compared to nonsmokers, tobacco smokers were younger, more frequently male and presented with fewer strok...
Connexins have been proposed as a target for therapeutic treatment of a variety of conditions. The main approaches have been by antisense or small peptides specific against connexins. Some of these peptides enhance communication while others interfere with connexin binding partners or bind to the intracellular and extracellular loops of connexins. Here, we explored the mechanism of action of a ...
Methods and Results-—Thirteen healthy young (23 2 years) and 13 older men (61 5 years) were instructed to continuously wear a compression sleeve around the right forearm to chronically (2 weeks) elevate brachial artery retrograde SR in 1 arm. We assessed SR, diameter, and flow-mediated dilation in both the sleeve and contralateral control arms at baseline and after 30 minutes and 2 weeks of con...
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