نتایج جستجو برای: 745 to 283
تعداد نتایج: 10615424 فیلتر نتایج به سال:
Oncogenic BRAF, which drives cell transformation and proliferation, has been detected in approximately 50% of human malignant melanomas and 5% to 15% of colorectal cancers. Despite the remarkable clinical activities achieved by vemurafenib and dabrafenib in treating BRAF(V600E) metastatic melanoma, their clinical efficacy in BRAF(V600E) colorectal cancer is far less impressive. Prior studies su...
Oncogenic BRAF, which drives cell transformation and proliferation, has been detected in approximately 50% of human malignant melanomas and 5% to 15% of colorectal cancers. Despite the remarkable clinical activities achieved by vemurafenib and dabrafenib in treating BRAF metastatic melanoma, their clinical efficacy inBRAF colorectal cancer is far less impressive. Prior studies suggested that fe...
To understand the situation of water contamination with Cryptosporidium spp. and Giardia spp. in the northern region of Portugal, we have established a long-term program aimed at pinpointing the sources of surface water and environmental contamination, working with the water-supply industry. Here, we describe the results obtained with raw water samples collected in rivers of the 5 hydrographica...
Explanation.................................................................................................... 275 Evaluation for acceptable daily intakes ........................................................ 276 Biochemical aspects ................................................................................ 277 Absorption distribution and excretion ........................................
Using a strategy related to intragenic suppression, we previously obtained evidence for structural interactions in the voltage sensor of Shaker K(+) channels between residues E283 in S2 and R368 and R371 in S4 (Tiwari-Woodruff, S.K., C.T. Schulteis, A.F. Mock, and D. M. Papazian. 1997. Biophys. J. 72:1489-1500). Because R368 and R371 are involved in the conformational changes that accompany vol...
Partially supported by the Project LN00A056 of the Czech Ministry of Education and by GAUK 158 grant. Research supported by the United States-Israel Binational Science Foundation. Publication 745 Math. Subj. Class.03C, 05C, 05E, and 06A.
1 Depressive Symptoms and Short Telomere Length Are Associated with Increased Mortality in Bladder Cancer Patients Jie Lin,* Janice A. Blalock,* Meng Chen, Yuanqing Ye, Jian Gu, Lorenzo Cohen, Paul M. Cinciripini, Xifeng Wu Departments of Epidemiology, 1155 Pressler, Unit Number 1340, Houston, TX 77030; Behavioral Science, 1155 Pressler, Unit Number 1330, Houston, TX 77030; General Oncology and...
The effect of omeprazole on the mitochondrial carnitine/acylcarnitine transporter has been studied in proteoliposomes. Externally added omeprazole inhibited the carnitine/carnitine antiport catalysed by the transporter. The inhibition was partially reversed by DTE indicating that it was caused by the covalent reaction of omeprazole with Cys residue(s). Inhibition of the C-less mutant transporte...
COFAC-Col: A Cervical Cancer Control Networking Initiative in Five French-Speaking African Countries Nicolas Berthet, Christine Berling, Hermann Nabi, Gis ele Woto Gaye, Coumba Toure Kane, Halimatou Diop-Ndiaye, Isma€ el Herv e Koumakpayi, Corine Engohan Aloghe, Ulrick Bisvigou, Judith Didi Coulibaly, Hortense Faye Kette, Emmanuel Koffi, Daniel Ekra, Pamela Moussavou Boundzanga, Ingrid Labouba,...
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