Cystic fibrosis (CF) is a lethal recessive genetic disease caused primarily by the F508del mutation in the CF transmembrane conductance regulator (CFTR). The potentiator VX-770 was the first CFTR modulator approved by the FDA for treatment of CF patients with the gating mutation G551D. Orkambi is a drug containing VX-770 and corrector VX809 and is approved for treatment of CF patients homozygou...

Objective: To use cluster analysis to identify psychological profiles and related mental health symptoms among male and female juvenile offenders. Method: Juvenile offenders (N = 141) incarcerated in the California Youth Authority completed the Minnesota Multiphasic Personality Inventory (MMPI) and the Massachusetts Youth Screening Instrument-Version 2 (MAYSI-2). Results: MMPI cluster analysis ...

in this article, we will estimate efficiency amountof decision-making unit by offering the continuous piecewise polynomialextrapolation and interpolation by ccr model input-oriented on the assumptionthat it is constant returns to scale in different times. and finally, we willestimate efficiency amount of decision-making unit indifferent times byoffering an example.

Periodic elections are the main instrument through which voters can hold politicians accountable. From this perspective term limits, which restrict voters’ ability to reward politicians with re-election, appear counterproductive. We show that despite the disciplining effect of elections, term limits can be ex ante welfare improving from the perspective of voters. By reducing the value of holdin...

Charter schools that provide nonclassroom-based (NCB) instruction have represented a rapidly proliferating segment in the charter school movement in California over the past decade. Nonclassroom-based charter schools differ from traditional charter schools in that they deliver instruction outside the confines of the classroom setting. Nonclassroom-based instruction encompasses home-schooling an...

We study the contributions of kaon pair originating from resonance $\ensuremath{\rho}(770)$ for three-body decays $B\ensuremath{\rightarrow}DK\overline{K}$ by employing perturbative QCD approach. According to predictions in this work, intermediate state $\ensuremath{\rho}(770{)}^{0}$ are relatively small such as ${B}^{0}\ensuremath{\rightarrow}{\overline{D}}^{0}{K}^{+}{K}^{\ensuremath{-}}$, ${B...

1Assistant Professor, Susquehanna University, 314 Steele Hall, Selinsgrove, PA 17870 (corresponding author: phone: 570-372-4186; fax: 570-372-2870; e-mail: [email protected]). 2Research Economist, RTI International, Research Triangle Park, NC 27709 (phone: 919-485-5579; fax: 919-541-6683; e-mail: [email protected]). 3Assistant Professor, Kenyon College, Gambier, OH 43022 (phone: 740-427-5281; fax: 7...