Sir, Once more correspondence columns have borne witness to the confusion caused by the Leeds exercise test. Yet again Professor Linden and his colleagues have been able to claim that their protocol has not been adhered to-and of course on this occasion they are correct in that respect.'2 They have, however, chosen to ignore other studies that have followed their protocol meticulously and that ...

dose-dependent pharmacokinetic of phenytoin necessitates the estimation of the maximum rate of metabolism (vm) and the michaelis-menten constant (km) in a concerned population. the aim of this study was to determine the pharmacokinetic parameters of phenytoin in a sample of iranian patients to optimize the antiepileptic pharmacotherapy. fourty patients who received a constant dose of phenytoin ...

Introduction: Studies have reported hyperlipidemia and its complications, such as diabetes, along with aging. Omentin-1, on the other hand, is a protein that is secreted in visceral adipose tissue and can increase insulin sensitivity. This study aimed at evaluating the effect of aerobic exercise on resting levels of omentin-1, C-reactive protein, and some metabolic parameters in middle-aged men...

Background: The present study aimed to investigate the equivalent dose in vital organs, including heart and lung, due to secondary particles produced during breast proton therapy. Materials and Methods: The numerical ORNL female-phantom was improved and simulated using the Monte Carlo MCNPX code. The depth-dose profile of proton beams with different energies was simulated. The proper energy ran...

The relationship between heart rate (HR) during exercise and exercise capacity in patients with heart failure due to left ventricular systolic dysfunction remains unclear. The accepted diagnostic criterion for chronotropic incompetence (CI), a maximum agepredicted heart rate (MA-PHR) 85%, is seen in 50% of patients with severe heart failure on contemporary medical therapy (1). Whether the lesse...