Bromination of visnagin (1) afforded 9-bromovisnagin (2) which on its alkaline hydrolysis afforded the 3-acetyl benzofuran derivative (3). The condensation of (3) with hydrazine hydrate, phenylhydrazine and/or hydroxylamine hydrochloride afforded the corresponding pyrazole derivatives (4a, b) and isoxazole derivative (4c). On the other hand, when compound 3 was condensed with some aromatic alde...

1. Loss Function Derivative In this section we outline the derivative of Equation 8 for the backpropagation algorithm; min U J = L(Us) + γM(Us, Ut) + ηH(Us, Ut), (8) where, U := {Us ∪ Ut} and (γ, η) control the importance of domain adaptation (1) and target entropy loss (7) respectively. In the following subsections, we outline the derivative of the individual terms w.r.t. the input U. 1.1. Der...

Effective treatments for osteoporosis remain fairly elusive; however, studies have reported that antioxidants may aid in the maintenance of reactive oxygen species at a favorable level, in order to prevent osteoporosis. Gallic acid (GA) and its derivatives are potent antioxidative and anti‑inflammatory agents that affect several biochemical and pharmacological pathways; however, GA is slightly ...

Faculdade de Ciências Farmacêuticas (FCF), Depto. de Ciências Biológicas, 6 Universidade Estadual Paulista (UNESP), Rod. Araraquara/Jau, Km 1, Araraquara, 7 SP, Brazil, 14801-902; Depto. de Química Orgânica, Instituto de Química, UNESP, 8 Av. Prof. Francisco Degni, s/n, Araraquara, SP, Brazil, 14800-900; Depto. Científico, 9 Fundecitrus , Av. Dr. Adhemar Pereira de Barros, 201, Araraquara, SP, ...

A key protected streptidine derivative (3) useful for the synthesis of antibiotics of streptomycin series was prepared by hydrolysis of an acylated dihydrostreptomycin (DHSM) derivative (2), and it was condensed with a protected dihydrostreptobiosaminyl chloride (5) to give two condensation products (6 and 7). By deblocking, 6 was led to DHSM and 7 to a biologically inactive isomer (8) of DHSM....

Hexaphenylbenzene (HPB) derivatives 5 and 7 having rhodamine B moieties have been designed and synthesized, and have been shown to display solvent dependent. Fluorescence resonance energy transfer (FRET) and through bond energy transfer (TBET) in the presence of Hg(2+) ions among the various cations (Cu(2+), Pb(2+), Zn(2+), Ni(2+), Cd(2+), Ag(+), Ba(2+), Mg(2+), K(+), Na(+), and Li(+)) have bee...