نتایج جستجو برای: 68ga psma petct scanning
تعداد نتایج: 162982 فیلتر نتایج به سال:
Prostate cancer can be targeted by ligands to the prostate-specific membrane antigen (PSMA). We aimed to evaluate dosimetry, safety and efficacy of 177Lu-PSMA-617 radioligand therapy (RLT) in patients with metastatic castration-resistant prostate cancer (mCRPC).Fifteen patients each received two cycles of 3.7 GBq (n = 5) or 6.0 GBq (n = 10) 177Lu-PSMA-617 at an eight to ten weeks interval. For ...
Prostate-specific membrane antigen (PSMA) is a cell surface glycoprotein expressed predominantly by prostate cancer cells. We have characterized four monoclonal antibodies that bind to the extracellular domain of PSMA (Liu et al., Cancer Res., 57: 3629-3634, 1997). Here we report that viable LNCaP cells internalize these antibodies. Laser scanning confocal microscopy reveals that the internaliz...
Tris(hydroxypyridinone) chelators conjugated to peptides can rapidly complex the positron-emitting isotope gallium-68 (68Ga) under mild conditions, and the resulting radiotracers can delineate peptide receptor expression at sites of diseased tissue in vivo. We have synthesized a dendritic bifunctional chelator containing nine 1,6-dimethyl-3-hydroxypyridin-4-one groups (SCN-HP9) that can coordin...
Kanker prostat merupakan kanker tersering kedua dan menjadi penyebab kematian kedelapan akibat pada laki-laki di dunia; Indonesia, kejadian berada urutan kelima sebesar 7,4% dari 183.368 kasus baru. Modalitas pencitraan struktural (USG, CT, MRI) pemeriksaan standar klinis sehari-hari, tetapi terbatas untuk staging prostat, restaging pasien dengan kekambuhan biokimia, serta menilai respons terap...
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