BACKGROUND This first-in-human phase I/IIA study was designed to evaluate the safety and pharmacokinetics (PKs) of AGS-PSCA a fully human monoclonal antibody directed to prostate stem cell antigen (PSCA) in progressive castration-resistant prostate cancer. PATIENTS AND METHODS Twenty-nine patients were administered infusions of AGS-PSCA (1-40 mg/kg) every 3 weeks for 12 weeks; 18 final patien...

Although flowering regulatory mechanisms have been extensively studied in Arabidopsis (Arabidopsis thaliana), those in other species have not been well elucidated. Here, we investigated the role of OsMADS51, a type I MADS-box gene in the short-day (SD) promotion pathway in rice (Oryza sativa). In SDs OsMADS51 null mutants flowered 2 weeks later than normal, whereas in long days loss of OsMADS51...

the flowering phase of apple trees is the most critical step in relation with low temperatures and frost events. therefore, forecasting the time of flowering is important. if a model can predict the exact time of flowering, it would be feasible to care for flowers agianst late spring freezing (lsf). in this study, we evaluated three temperature-base chilling models namely: chilling hours (ch), ...

flowering and fruit production of ‘nagami’ kumquat is somewhat different from other citrus species because usually have three flowering peak in a year which can lead to producing fruits with different quality on a tree. considering the proper effect of paclobutrazol on raising citrus flowering, a pot experiment with three levels of paclobutrazol (zero, 0.1 and 0.5 g ai per tree) and six replica...

Connection between the developmental stage and the quantity and quality of essential oil was investigated in some model species of the Asteraceae, Lamiaceae and Apiaceae plant families. The accumulation of essential oil decreased continuously during ontogenesis in Tanacetum vulgare. The tendency of accumulation showed an optimum curve in Mentha piperita, Hyssopus officinalis, Majorana hortensis...

in order to study the effects of different irrigation regimes and nitrogen fertilizer levels on yield and yield components of chickpea (ilc482), a field experiment involving chickpea genotype ilc482 was conducted as factorial arrangement based on a randomized complete block design with four replications in the agricultural research station, ferdowsi university of mashhad during growing season o...

Introduction: Diabetes mellitus has adverse effects on male sexual and reproductive functions in human and animals. Diabetes results in reduced fertility and libido. Medicinal plants have attracted much attention in controlling many diseases such as diabetes. In the present study, we aimed to investigate the effect of garlic juice on testicular damage. Methods: Forty male rats (250±20) wer...

In the present study effects of production history on tuber sprout, root, stem development and crop yield of seed potato cultivars Fambo and Van Gogh were investigated in the High Grade Area of Finland (64.9 N, 25.4 E). The haulms of seed potatoes were destroyed at the time of flowering (50 days after planting, DAP), three weeks after flowering (75 DAP) and as a control the haulm was left to na...

†Background and Aims Ageing effects may be due to dysfunction leading to decreasing reproduction and survival with age. In plants, however, other (physiological) causes, associated with size for example, may also play a role. Iteroparous plants with genetically variable life spans can be helpful in unravelling these two aspects of changes associated with growing older. †Methods In a long-term e...