Polyunsaturated omega-3 fatty acids (omega-3 PUFA) are important components of cell membrane affecting its function and their deficiency is deleterious to health. We have previously shown that spontaneously hypertensive rats (SHR) are prone to life-threatening arrhythmias that are reduced by omega-3 PUFA intake. Purpose of this study was to explore plasma and red blood cells (RBC) profile of om...

A high omega-6/omega-3 ratio, as is found in today's Western diets, promotes the pathogenesis of many chronic diseases, including cardiovascular disease. Increased dietary intake of linoleic acid (LA) leads to oxidation of low-density lipoprotein (LDL), platelet aggregation, and interferes with the incorporation of essential fatty acids (EFA) in cell membrane phopholipids. Both omega-6 and omeg...

Increasing evidence implicates functional deficiencies or imbalances of omega-3 and omega-6 fatty acids in dyslexia. The associations between literacy skills and omega-3 and omega-6 fatty acid status were examined. 32 dyslexics and 20 controls completed standardised tests of reading and spelling and gave venous blood samples for analysis of the polar lipid fatty acid composition of red blood ce...

Let $\Omega\subset \mathbb{R}^3$ be a Lipschitz domain and let $S_\mathrm{curl}(\Omega)$ the largest constant such that $$ \int_{\mathbb{R}^3}|\nabla\times u|^2\, dx\geq S_{\mathrm{curl}}(\Omega) \inf_{\substack{w\in W_0^6(\mathrm{curl};\mathbb{R}^3)\\ \nabla\times w=0}}\Big(\int_{\mathbb{R}^3}|u+w|^6\,dx\Big)^{\frac13} for any $u$ in $W_0^6(\mathrm{curl};\Omega)\subset W_0^6(\mathrm{curl};\mat...

Metabolic endotoxemia, commonly derived from gut dysbiosis, is a primary cause of chronic low grade inflammation that underlies many chronic diseases. Here we show that mice fed a diet high in omega-6 fatty acids exhibit higher levels of metabolic endotoxemia and systemic low-grade inflammation, while transgenic conversion of tissue omega-6 to omega-3 fatty acids dramatically reduces endotoxemi...