نتایج جستجو برای: 5ht1a
تعداد نتایج: 161 فیلتر نتایج به سال:
Introduction : The present study is aimed at investigation of the mechanism action a new 3-substituted thietane-1,1-dioxide derivative (N-199/1) exhibiting antidepressant properties, in several tests neuropharmacological interaction. Materials and methods To N-199/1, its effect on 5-hydroxytryptophan (5-HTP)-induced head-twitch response (50 mg/kg 300 mg/kg), haloperidol-induced catalepsy (1 are...
To identify new leads for the treatment of Plasmodium falciparum malaria, we screened a panel of serotonin (5-hydroxytryptamine [5HT]) receptor agonists and antagonists and determined their effects on parasite growth. The 5HT1A receptor agonists 8-hydroxy-N-(di-n-propyl)-aminotetralin (8-OH-DPAT), 2,5-dimethoxy-4-iodoamphetamine, and 2,5-dimethoxy-4-bromophenylethylamine inhibited the growth of...
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Fusion proteins were generated between the human 5-hydroxytryptamine (5-HT)1A receptor and both wild-type (Cys ) and pertussis toxin-resistant (Gly and Ile) forms of Gi1. These were expressed stably. Pertussis toxin treatment substantially reduced basal high-affinity GTPase activity in clones expressing the 5-HT1A receptor wild-type Gi1a construct but not in clones expressing 5-HT1A receptor (G...
s: Burggren AC, Martin-Harris L, Suthana NS, Donix M, Ekstrom A, Jones M, Renner B, Kepe V, S-C Huang, Barrio JR, Ercoli LM, Miller KJ, Siddarth P, Small GW, Bookheimer SY. Correlation of cortical thickness within the medial temporal lobe to PET measures of brain amyloid and tau. Human Brain Mapping Conference June 2009.
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