A series of amide (8–32, 40–45) and urea (33, 34, 36–39) analogues based on the thiaplakortone A natural product scaffold were synthesised and screened for in vitro antimalarial activity against chloroquine-sensitive (3D7) and chloroquine- and mefloquine-resistant (Dd2) Plasmodium falciparum parasite lines. Several analogues displayed potent inhibition of P. falciparum growth (IC50 <500 nM) and...

Abstract Intel includes in its recent processors a powerful set of instructions capable processing 512‐bit registers with single instruction (AVX‐512). Some these have no equivalent earlier sets. We leverage to efficiently transcode strings between the most common formats: UTF‐8 and UTF‐16. With our novel algorithms, we are often twice as fast previous best solutions. For example, Chinese text ...

BACKGROUND Inflammation and oxidative stress (OxS) contribute to the pathogenesis of diabetic kidney disease (DKD) and contrast-induced nephropathy (CIN). Patients with DKD were found to be more prone to CIN. Interleukin-33 (IL-33) is a proinflammatory cytokine, but its role in DKD and CIN is unknown. METHODS Thirty male Sprague-Dawley rats were enrolled. The first group was comprised of heal...

Temperature-gradient microstructure and nutrient profiling were undertaken at both an inshore and an offshore site on Mono Lake, California, to determine whether boundary mixing occurred and the effects on nutrient flux within the lake. Turbulence, as quantified by rates of dissipation of turbulent kinetic energy, was two to three orders of magnitude higher at the inshore site where the pycnocl...

On August we completed the factorization of the bit digit number RSA with the help of the Number Field Sieve factoring method NFS This is a new record for factoring general numbers Moreover bit RSA keys are frequently used for the protection of electronic commerce at least outside the USA so this factorization represents a breakthrough in research on RSA based systems The previous record factor...

The capsid proteins VP2 and VP3 of infectious bursal disease virus, a birnavirus, are derived from the processing of a large polyprotein: NH2-pVP2-VP4-VP3-COOH. Although the primary cleavage sites at the pVP2-VP4 and VP4-VP3 junctions have been identified, the proteolytic cascade involved in the processing of this polyprotein is not yet fully understood, particularly the maturation of pVP2. By ...

Utilization and requirement of egg protein in Japanese women with two levels of energy intake were estimated. In experiment 1, fifteen female students were given semi-purified diet containing whole egg as the sole nitrogen source for 12 days. Nitrogen intakes were 50 for five, 75 for two and 100 mg N/kg for eight subjects. Habitual energy intake was determined individually by detailed inquiry a...

1. Even periodic ring theories and formal group laws 1 2. Formal groups 5 3. Geometry of formal groups 8 4. Heights of formal groups 12 5. Homology of Z× BU and related spaces 15 6. The Thom isomorphism 19 7. Elliptic spectra 24 8. The generalized Weierstrass equation 25 9. Modular forms 29 10. Elliptic curves and the group structure 30 11. Weierstrass parameters and Thom spectrum of ΩU(4) 33 1...