A basal calpain activity promotes the limited proteolysis of wild type (WT) cystic fibrosis conductance regulator (CFTR), inducing the internalization of the split channel. This process contributes to the regulation in the level of the active CFTR at the plasma membranes. In peripheral blood mononuclear cells (PBMC) from 16 healthy donors, the inhibition of calpain activity induces a 3-fold inc...

Expression of the cystic fibrosis transmembrane conductance regulator (CFTR) is stringently controlled by molecular chaperones participating in formation of the quality control system. It has been shown that about 75% of all CFTR protein and close to 100% of the [DeltaPhe(508)] CFTR variant are rapidly degraded before leaving the endoplasmic reticulum (ER). B cell antigen receptor-associated pr...

Recent advances in our understanding of translational dynamics indicate that codon usage and mRNA secondary structure influence translation and protein folding. The most frequent cause of cystic fibrosis (CF) is the deletion of three nucleotides (CTT) from the cystic fibrosis transmembrane conductance regulator (CFTR) gene that includes the last cytosine (C) of isoleucine 507 (Ile507ATC) and th...

Abstract Aim Temporomandibular Joint (TMJ) osteoarthritis (OA) is a common type of arthritis that affects all ages. Currently conservative treatment 1st line for in the TMJ and surgical should only be considered as last resort. This study aims to assess whether nutraceuticals can provide any symptomatic relief OA. Method A total 10 studies were identified using electronic databases, no exclusio...

We analysed (i) the gender difference in cycling speed and (ii) the age of winning performers in the 508-mile "Furnace Creek 508". Changes in cycling speeds and gender differences from 1983 to 2012 were analysed using linear, non-linear and hierarchical multi-level regression analyses for the annual three fastest women and men. Cycling speed increased non-linearly in men from 14.6 (s = 0.3) km ...

MECHANISM OF TARGETING............................................................................................ 501 Signal Recognition Particle ...................................................................................... 502 Signal Sequences ............................................................. ............................. ..... ....... 507 SRP Receptor ............ . . .....

2. Lotfi M, Hamblin MR, Rezaei N. COVID-19: Transmission, prevention, and potential therapeutic opportunities. Clin Chim Acta. 2020 Sep; 508: 254–266. https://doi.org/10.1016/j.cca..... CrossRef Google Scholar

1 PI3K/PKB PATHWAY AND TAUROCHOLATE UPTAKE IN HUH-NTCP CELL LINE 2 3 Christopher M. Schonhoff, Ai Yamazaki, Simon Hohenester, Cynthia R.L. Webster, 4 Bernard Bouscarel, M. Sawkat Anwer 5 6 Departments of Biomedical and Clinical Sciences, Tufts Cummings School of 7 Veterinary Medicine North Grafton, Massachusetts; Medicine II, University of Munich 8 Medical Center, Munich, Germany; Gastroenterol...

The intravenous injection of an ultrasound contrast agent can enhance signals from blood flow. Broad toxicological and pharmaceutical studies in animals confirmed the safety and efficacy of an ultrasound contrast agent made of microparticles of galactose with stabilised microbubbles in watery suspension (SH U 508 A). In this paper 10 patients with different malignant orbital and ocular tumours ...