Fapy.dG and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) are formed in DNA by hydroxyl radical damage. In order to study replication past these lesions in cells, we constructed a single-stranded shuttle vector containing the lesion in 5'-TGT and 5'-TGA sequence contexts. Replication of the modified vector in simian kidney (COS-7) cells showed that Fapy.dG is mutagenic inducing primarily targe...

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The asymmetric unit of the polymeric title compound, [Mg(3)(C(9)H(3)O(6))(2)(C(3)H(7)NO)(4)](n), contains three Mg(II) ions bridged by carboxyl-ate O atoms from two fully deprotonated benzene-1,3,5-tricarboxyl-ate (BTC) trianions and four metal-coordinated dimethyl-formamide (DMF) mol-ecules. One Mg(II) ion is octa-hedrally coordinated by six carboxyl-ate O atoms. The other two cations are each...

A new methylated flavonol, 5,7,2',4'-tetrahydroxy-3-methoxyflavone (1), had been isolated from the methanol extract of the wood of Morus australis, along with nine known compounds, kuwanon C (2), morusin (3), morachalcone A (4), oxyresveratrol (5), 4'-(2-methyl-2-buten-4-yl)oxyresveratrol (6), moracins M (7) and C (8), alboctalol (9), and macrourin B (10). The structures of these compounds were...