نتایج جستجو برای: 5 hydroxymethyl meloxicam

تعداد نتایج: 1218879  

Journal: :Physiological research 2008
M Hofer M Pospísil V Znojil J Holá A Vacek D Streitová

Hematopoiesis-modulating action of meloxicam, a cyclooxyge-nase-2 inhibitor, has been evaluated in mice. Increased serum level of granulocyte colony-stimulating factor (G-CSF) after meloxicam administration has been found in sublethally gamma-irradiated animals. In further experiments hematopoiesis-stimulating effects of meloxicam and G-CSF given alone or in combination have been investigated. ...

Journal: :Molecules 2011
Qiu-Hong Wang Liu Yang Hai Jiang Zhi-Bin Wang Bing-You Yang Hai-Xue Kuang

Three new phytoecdysteroid compounds, named niuxixinsterone A (1), B (2) and C (3) with acetal functions in the side-chain were isolated from Achyranthes bidentata Bl. The structures were established as (20R,22R,24S)-20-O,22-O-(5'-hydroxymethyl)-furfurylidene-2β,3β,14α,25-tetrahydroxy-5β-ergost-7-en-6-one (1), (20R,22R)-20-O,22-O-(5'-hydroxymethyl)-furfurylidene-2β,3β,25-trihydroxy-14β-methyl-1...

1998
Mariam H. Yousif Olav Thulesius

Objective: To test the potentially toxic urinary tract effects of indomethacin in comparison with a novel COX-2 inhibitor, meloxicam. Method: In vitro experiments were performed using isolated ring segments of sheep ureter mounted in organ-baths. Changes in isometric tension and frequency of rhythmic contractions were assessed in control and lipopolysaccharide (LPS)-treated preparations prior t...

2015
Daniel Gackowski Ewelina Zarakowska Marta Starczak Martyna Modrzejewska Ryszard Olinski Wendy Dean

BACKGROUND Replication-independent active/enzymatic demethylation may be an important process in the functioning of somatic cells. The most plausible mechanisms of active 5-methylcytosine demethylation, leading to activation of previously silenced genes, involve ten-eleven translocation (TET) proteins that participate in oxidation of 5-methylcytosine to 5-hydroxymethylcytosine which can be furt...

Journal: :Bulletin of the Chemical Society of Japan 1979

Journal: :The Journal of the Society of Chemical Industry, Japan 1957

Journal: :iranian journal of pharmaceutical research 0
mh dehghan m jafar

meloxicam is a poorly water soluble non steroidal anti-inflammatory drug and antipyretic agent. the aim of the present work was to investigate the effect of different types of carriers on in vitro dissolution of meloxicam. meloxicam solid dispersions were prepared by physical mixing, co-grinding and solvent evaporation methods with polyethylene glycol (peg) 6000. the effect of solubilization by...

Journal: :Carcinogenesis 2006
Takahiro Naruse Yoshihiro Nishida Kozo Hosono Naoki Ishiguro

Cyclooxygenase-2 (COX-2) inhibitors exert antitumor activity via COX-2-dependent and independent pathways. We wished to evaluate the antitumor activity of meloxicam, a preferential COX-2 inhibitor, in osteosarcoma, the most common primary malignant bone tumor, and determine whether its antitumor effect is COX-2-dependent. COX-2 expression in the osteosarcoma cell lines MG-63, HOS and U2-OS was ...

Journal: :American journal of physiology. Endocrinology and metabolism 2007
Miriam Granado Ana I Martín Maria Angeles Villanúa Asunción López-Calderón

Chronic arthritis induces cachexia associated with an inhibition of the growth hormone (GH)-insulin-like growth factor-I (IGF-I) system and an activation of the E3 ubiquitin-ligating enzymes muscle atrophy F-box (MAFbx) and muscle Ring finger 1 (MuRF1) in the skeletal muscle. The aim of this work was to study the role of cyclooxygenase (COX)-2 in chronic arthritis-induced cachexia. Arthritis wa...

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