Amikacin 5 mg/kg q 48 hr IM for 5-14 tx Maruska 1994 Carbenicillin 200 mg/kg SQ, IM, or IC q 24 hr Crawshaw 1992 Ceftazadime 20 mg/kg IM q 48-72 hr Wright and Whitaker 2001 Chloramphenicol 50 mg/kg SQ, IM or IC q 24 hr; 20 mg/L bath; 10 mg/mL in 0.5% saline as 24-hr bath Crawshaw 1992; Crawshaw 1992; Menard 1984 Ciprofloxacin 10 mg/kg PO q 24-48 hr for 7 tx; 25-37.5 mg/gal for 6-8 hr bath q 24 ...

The cross-sensitization to stereotyped behavior between mazindol (MZD) and methamphetamine (MAP) was investigated in rats. MZD (5 and 10 mg/kg/day, p.o.), MAP (5 and 10 mg/kg/day, p.o.) and saline (1 ml/kg, p.o.) were administered once daily for a week. Challenge with MZD (10 mg/kg, p.o.) on the 8th day caused markedly stereotyped behavior in MAP-pretreated group compared with the saline-pretre...

The influence of calcium channel antagonists on the behavioral sensitization to nicotine-induced hyperlocomotion and place preference was investigated. Locomotor sensitization in mice was produced by injecting nicotine (0.5 mg/kg, i.p.) for 5 consecutive days before placement in an apparatus in which locomotor activity was evaluated for 1 h. One week later, activity of mice was recorded after c...

Effect of pretreatment of intraperitoneally administered Ca-channel blockers Nifedipine (5, 10, 20 mg/kg). Verapamil (5, 10, 20 mg/kg) and Diltiazem (5, 10, 20 mg/kg) was studied on Haloperidol-induced catalepsy and Methamphetamine-induced stereotypy in albino rats. All these drugs reduced the onset of catalepsy, significantly increased the cataleptic score and delayed the onset and inhibited t...

Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on limited availability of drugs that are safe and efficacious, particularly against the second stage (central nervous system [CNS]) of infection. In response to this largely unmet need for new treatments, the Consortium for Parasitic Drug Development developed novel parenteral diamidin...

Antiarrhythmic effects of intravenous coronary vasodilators (verapamil, diltiazem, bepridil, trimetazidine and nicorandil) were evaluated using two canine ventricular arrhythmia models (halothane-adrenaline arrhythmia and digitalis arrhythmia), and the minimum effective plasma concentrations of the drugs were determined for each arrhythmia model. Verapamil (0.1 mg/kg), diltiazem (0.1 mg/kg), be...

background and aims: inflammation is one of the defense mechanisms of body and unpleasant sensation of pain is caused by tissue damage. mostly, inflammation occurs through the release of inflammatory mediators. salvia officinalis is one of the most valuable medicinal kind of mint order. salvigenin is one of the active flavonoids existing in this plant. the aim of this study was to evaluate the ...

Little is known about analgesia in lower vertebrates such as the Speke's hinged tortoise (Kinixy's spekii), yet of late they are increasingly being adopted as pets. The effects of morphine (5, 7.5, 10 and 20 mg/kg), pethidine (10, 20, and 50 mg/kg) and naloxone (5 mg/kg) on nociception induced by the formalin test (12.5%, 100 microL) were studied in the Speke's hinged tortoise. Formalin induced...