That Thiadiazoles derivative is biologically active as antimicrobial agents in cooling fluids.
 Derivatives of 1, 3, 4- thiadiazole have prepared:
 
 2-amino-3-[(2-amino-1, 4-thiadiazol-5-yl) dithio] propanoic acid.
 2-(2-Carbethoxyamino-1, 4-thiadiazol-5-yl)-thio acetic [(5-amino-1,3,4-thiadiazol-2-yl) acid
 The synthesized compounds been used against the microorganism...