A new series of 6 dimeric trioxane sulfones has been prepared from the natural trioxane artemisinin in five or six chemical steps. One of these thermally and hydrolytically stable new chemical entities (4c) completely cured malaria-infected mice via a single oral dose of 144 mg/kg. At a much lower single oral dose of only 54 mg/kg combined with 13 mg/kg of mefloquine hydrochloride, this trioxan...

Received ; accepted – 2 – ABSTRACT Near-infrared images of the luminous, high redshift (z = 2.1108) radio loud quasar 4C +09.17 reveal a complex structure. The quasar (K= 15.76 mag) is surrounded by three " companion " objects having 17.9 < K < 20.2 mag at radii of 1.7 ′′ < ∆r< 2.9 ′′ , as well as bright, diffuse emission. The brightest companion has a redshift of z = 0.8384 (Lehnert & Becker 1...

The ability to correlate chromosome conformation and gene expression gives a great deal of information regarding the strategies used by a cell to properly regulate gene activity. 4C-Seq is a relatively new and increasingly popular technology where the set of genomic interactions generated by a single point in the genome can be determined. 4C-Seq experiments generate large, complicated data sets...

This study compared body composition by dual-energy X-ray absorptiometry (DEXA; Lunar DPX-L) with that via a four-compartment (4C; water, bone mineral mass, fat, and residual) model. Relative body fat was determined for 152 healthy adults [30.0 +/- 11.1 (SD) yr; 75.10 +/- 14.88 kg; 176.3 +/- 8.7 cm] aged from 18 to 59 yr. The 4C approach [20.7% body fat (%BF)] resulted in a significantly (P < 0...

We present near-infrared imaging and spectroscopic observations of two FR II high-redshift radio galaxies (HzRGs), 4C 40.36 (z = 2.3) and 4C 39.37 (z = 3.2), obtained with the Hubble, Keck, and Hale Telescopes. High resolution images were taken with filters both in and out of strong emission lines, and together with the spectroscopic data, the properties of the line and continuum emissions were...

Let Bn be an aperiodic Brandt semigroup M0[G;n, n;P ] where G is the trivial group, n ∈ N and P = (aij)n×n with aij = 1G if i = j and aij = 0 otherwise. The maximum size of an independent set in Bn is known to be bn2/4c+n, where bn2/4c denotes the largest integer not greater than n2/4. We reprove this result using Turán’s famous graph theorem. Moreover, we give a characterization of all indepen...

The role of human cytochrome P450 (CYP) in the metabolic activation of tobacco-related N-nitrosamines was examined by Salmonella mutation test using a series of genetically engineered Salmonella typhimurium YG7108 strains each co-expressing a form of CYP (CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4, and CYP3A5) together with human NADPH-cytochrome P450 reduct...