BACKGROUND Cysteinyl-leukotrienes are mediators of inflammatory responses in bronchial asthma. We studied the genes encoding the enzymes involved in their synthesis to identify risk factors for asthma. The promoter polymorphisms LTC4S -444 A/C, ALOX5 -176/-147, and ALOX5AP -169/-146 have been reported to be associated with bronchial asthma. METHODS We analyzed the effects of LTC4S -444 A/C, A...

Margien L Seinen*,1, Nanne KH de Boer1, Adriaan A van Bodegraven1,2, Stephen B Hanauer3 & Frank Hoentjen4 Department of Gastroenterology, VU University Medical Center, Amsterdam, The Netherlands Department of Internal Medicine, Gastroenterology & Geriatrics, ORBIS Medical Center, The Netherlands Digestive Health Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Infla...

Gastric cancer (GC) is among the most frequent types of cancer worldwide. Therefore, understanding the biology of GC tumorigenesis is important for appropriate diagnosis and patient surveillance. The miR-191/425 cluster has been reported to be overexpressed in various human cancers, but the tumorigenic role and clinical significance of miR-191/425 overexpression in gastric carcinogenesis is cur...

We report early FUSE observations of the very hot DA white dwarfs PG1342+444 and REJ0558−371. Detection of photospheric absorption lines allows us to estimate the abundances of C, O, Si, P, S and Fe, the first measurements reported for DA stars at such high temperatures. Values of T eff and log g determined for PG1342+444 from the Lyman line series disagree with the results of the standard Balm...

Surface Detail: We have discussed the use of lighting as a method of producing more realistic images. This is fine for smooth surfaces of uniform color (plaster walls, plastic cups, metallic objects), but many of the objects that we want to render have some complex surface finish that we would like to model. In theory, it is possible to try to model objects with complex surface finishes through...

‘‘Peepers’’ (dialysis samplers) rely on exchange across a dialysis membrane between fluid-filled cells and the surrounding sediment in order to sample the pore water at various depths. In the current study, we show that under some realistic circumstances, where there is a large density difference between the pore water and the cell fluid in permeable sediments, the resulting convective motion i...

J. Sichelschmidt, H.J. Im, S. Kimura, V. Voevodin, H. Rosner, W. Schnelle, A. Leithe-Jasper, J.A. Mydosh, Yu. Grin, F. Steglich Max Planck Institute for Chemical Physics of Solids, 01187 Dresden, Germany School of Physical Sciences, The Graduate University for Advanced Studies, Okazaki 444-8585 Japan UVSOR Facility, Institute for Molecular Science, Okazaki 444-8585 Japan II. Physikalisches Inst...