We investigated the effects of ketoconazole on the oral bioavailability of morpholine-urea-phenylalanine-homophenylalanine-vinylsulfone-phenyl (K02), a vinylsulfone peptidomimetic cysteine protease inhibitor, and a P450 3A (CYP3A) and P-glycoprotein dual substrate, in male Sprague-Dawley rats, so as to evaluate the roles of CYP3A and P-gp in K02 disposition. Male Sprague-Dawley rats (8-10 wk ol...

Depressor and renal activities of atrial natriuretic factor-(99-126) were determined in conscious, unrestrained spontaneously hypertensive rats treated with a neutral endopeptidase inhibitor, SQ 29,072 (7-[[2-(mercaptomethyl)-1-oxo-3-phenylpropyl]amino]heptanoic acid). SQ 29,072 (100 mumol/kg i.v.) prolonged the transient depressor effects of the peptide for as long as 2 hours. During the first...

Changes in fermenter gas composition within a given 24h period can cause severe bias in calculations of biogas or energy yields based on just one or two measurements of gas composition per day, as is common in other studies of two-stage fermentation. To overcome this bias, real time recording of gas composition and production were used to undertake a detailed and controlled comparison of single...

From the ‡Center for Craniofacial Molecular Biology and **Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California 90033 and ¶Department of Molecular and Integrative Physiology, University of Michigan Medical School, Michigan 48109-0622, USA. Running Title: Mouse amelogenin gene regulation §Address correspondence to: Malcolm L. Snead, CSA 142,...

In this work we present a comparison of the current SCIAMACHY and MERIS reflectance calibrations at wavelengths between 442 and 885 nm. For that purpose we, firstly, locate all the SCIAMACHY pixels within a given MERIS image and, secondly, we calculate the median and standard deviation of all the MERIS pixels (≈1000) within each SCIAMACHY pixel. Results show that SCIAMACHY underestimates the re...

http://ard.bmj.com/content/68/3/442.full.html Updated information and services can be found at: These include: References http://ard.bmj.com/content/68/3/442.full.html#ref-list-1 This article cites 10 articles, 4 of which can be accessed free at: service Email alerting box at the top right corner of the online article. Receive free email alerts when new articles cite this article. Sign up in th...

  Tuberculosis is a serious global public health problem and its high prevalence is stron gly associated with the enhancement of drug resistance. In this study we demonstrate a multiplex allele-specific polymerase chain reaction (MAS)-PCR assay to simultaneously detect mutations in the first and third bases of the embB gene codon 306 ATG in ethambutol (EMB) resistant isolates of Mycobacterium t...