However, little attention has been devoted to studying multivariate measurements. In particular, we have yet to develop tools to study relationships between measurements. Consider the following examples Example 1.1. Suppose you want to study the relationship between the height of a boy and his father. Here, we take two measurements per child, the child’s height and his/her father’s height, and ...

Question 1 Détail des schémas. Schéma explicite : u k − uk ∆t = uk−1 − 2uk + uk+1 ∆x , en d’autres termes, en notant λ := ∆t/∆x, (1) u k = λu n k−1 + (1− 2λ)uk + λuk+1. (2) On sait d’après le cours que ce schéma est d’ordre 1 en temps et 2 en espace. Il est stable dans L sous condition CFL λ ≤ 1 2 . Schéma de Crank-Nicolson : u k − uk ∆t = 1 2 ( u k−1 − 2u n+1 k + u n+1 k+1 ∆x + uk−1 − 2uk + uk...

In the course of studies to detect specific inhibitors of cholesterol synthesis from microbial products, several compounds were isolated from the culture broth of Penicillium dtrinum.^ One compound, sodium (+)-(3i?,5i?)-3,5-dihydroxy7-[(l S,2S,6S,8£,8ai?)-6-hydroxy-2-methyl8 [(£)2-methylbutyryloxy] 1 , 2, 6, 7, 8, 8a-hexahydro1naphthyl]heptanoate (CS-514) (la, pravastatin sodium) found as a min...

A phase III clinical trial showed gemcitabine chemotherapy combined with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib significantly improved overall survival in patients with advanced pancreatic cancer. Therefore, we studied whether addition of gemcitabine to erlotinib in cancer cells having intrinsic or acquired erlotinib resistance could restore chemosensitizati...

Correspondence: Khosrow Kashfi Department of Physiology, Pharmacology, and Neuroscience, City University of New York Medical School, 138th Street and Convent Avenue, New York, NY, USA 10031 Tel +1 212 650 6641 Fax +1 212 650 7692 Email [email protected] Background: The Wnt/β-catenin/T cell factor (TCF) signaling pathway is important in the development of nonmelanoma skin cancers (NMSCs). Nitr...

Multiple regression is an extension to simple regression in several ways. First, instead of examining a linear relationship bewteen two measurements, Xi and Yi, multiple regression aims to explain relationships between p measurements of an object i, denoted as (Xi,1, ..., Xi,p) and Yi. Based on a sample of n points, with each point having measurements (Yi, Xi,1, ..., Xi,p), multiple regression ...

In model selection, we seek a relationship between Y and X,1, ..., X,p that is parsimonious, but still retains good predictive power, as represented by the SSE. Each subset of X,1, ..., X,p that will be used for the fit is one particular model, denoted as M, for studying the relationship between Y and X,1, ..., X,p and we want to choose a subset ofX,1, ..., X,p that achieves this goal. The sele...

The TSP has countless practical applications. One very interesting application, albeit perhaps less practical than others, is TSP-art: scatter nodes of the graph in a square containing a given image, with a node density per surface unit which is proportional to the image colour wavelength; the cost of each arc is then the Euclidean distance between two nodes on the square. Minimum cost tours th...

BACKGROUND The Wnt/β-catenin/T cell factor (TCF) signaling pathway is important in the development of nonmelanoma skin cancers (NMSCs). Nitric-oxide-releasing nonsteroidal anti-inflammatory drugs (NO-NSAIDs) are chemopreventive agents consisting of a traditional NSAID attached to an NO-releasing moiety through a chemical spacer. Previously we showed that an aromatic spacer enhanced the potency ...

BACKGROUND AND PURPOSE The validity of hospital discharge diagnoses is essential in improving stroke surveillance and estimating healthcare costs of stroke. The aim of this study was to assess sensitivity, positive predictive value, and accuracy of discharge diagnoses compared with a stroke register. METHODS A record linkage was made between a population-based stroke register and the discharg...