Skin barrier properties are critical for maintaining epidermal water content, protecting from environmental factors, and providing first line of defense against pathogens. In this study, the effect a non-proteinogenic amino acid, L-4-Thiazolylalanine (L4), on important aspect skin health was evaluated by in vitro vivo biomarkers. 3D human models were treated with 0.3% L4. After 48h, RNA samples...

Streptococcus iniae is a major fish pathogen producing invasive infections that result in economic losses in aquaculture. Development of in vitro models of S. iniae virulence may provide insight to the pathogenesis of infection in vivo. Three S. iniae strains (K288, 94-426, and 29178) were tested for virulence in a hybrid-striped bass (HSB) model using intraperitoneal injection. S. iniae strain...

The clinical Staphylococcus epidermidis isolate 426-3147L exhibits an unusually high resistance to linezolid that exceeds 256 μg/ml. The presence of the cfr gene, encoding the RNA methyltransferase targeting an rRNA nucleotide located in the linezolid binding site, accounts for a significant fraction of resistance. The association of cfr with a multicopy plasmid is one of the factors that contr...

We fill a gap in the proof of a (rather critical) lemma, Lemma B.1, in Jin and Zhou [Mathematical Finance, Vol. 18 (2008), pp. 385–426]. We also correct a couple of other minor errors in the same paper.

Next-generation sequencing (NGS) from SARS-CoV-2-positive swabs collected during the last months of 2022 revealed a large deletion spanning ORF7b and ORF8 (426 nt) in six patients infected with BA.5.1 Omicron variant. This extensive genome loss removed part these two genes, maintaining frame first 22 aminoacids three ORF8. Interestingly, deleted region was flanked by small repeats, which were l...

OBJECTIVE To investigate the incidence of erectile dysfunction (ED) in men with lower urinary tract symptoms (LUTS) and the correlation between LUTS and ED. METHODS We enrolled 1 000 men aged 40 - 80 years with regular sex partners, evaluated their erectile function using IIEF-5, and investigated LUTS among them by International Prostate Symptom Score (IPSS). We studied the relationship betwe...

We have examined 426 Voyager fields distributed across the sky for O VI (λλ 1032/1038Å) emission from the Galactic diffuse interstellar medium. No such emission was detected in any of our observed fields. Our most constraining limit was a 90% confidence upper limit of 2600 photons cm −2 sr −1 s −1 on the doublet emission in the direction (l, b) = (117. • 3, 50. • 6). Combining this with an abso...

We aimed to investigate the association of inflammation-related genes such as IL-10, IL-6 and IL-1B with risk of ischemic stroke. We included 426 cases with ischemic stroke and 426 health controls from Xinxiang, China. Genomic DNA was extracted from the buffy coat layer of collected blood with the TIANamp blood DNA kit. Diabetes, hypertension, obesity, and smoking habits were associated with ri...