Escherichia coli ribonucleotide reductase (RNR), an alpha2beta2 complex, catalyzes the conversion of nucleoside 5'-diphosphate substrates (S) to 2'-deoxynucleoside 5'-diphosphates. alpha2 houses the active site for nucleotide reduction and the binding sites for allosteric effectors (E). beta2 contains the essential diferric tyrosyl radical (Y(122)(*)) cofactor which, in the presence of S and E,...

A genetic screen of transgenic mouse strains, carrying multiple copies of an MPSV neo retroviral vector, has led to the identification of a recessive embryonic lethal mutation, termed 413.d. This mutation is associated with a single proviral insertion and when homozygous, results in the failure of the early postimplantation embryo at the gastrulation stage of development. Embryonic stem cell li...

The Bcr-Abl oncoprotein is the primary causative factor in Philadelphia chromosome-associated leukemias. The activated tyrosine kinase of the Bcr-Abl oncoprotein is the primary driving force behind its oncogenic activity. We report here that a deleted form of Bcr [Bcr(64-413)], encompassing the Abl SH2 binding domains of Bcr, reduced the phosphotyrosine content of c-Abl and Bcr-Abl within cells...

194 words Pages Count 21 for main text Tables 4 Figures 5 ADDRESS CORRESPONDENCE TO: Kevin N. Ochsner Department of Psychology Columbia University 1190 Amsterdam Avenue New York, NY 10027 Tel: (212) 854-5548 Fax: (413) 845-3695 [email protected]

P.40k INTRODUCTION. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 405 Homozygosity after eight generations. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 407 Homozygosity after fourteen generations. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

Motorola, Phoenix Corporate Research Laboratories, 2100 East Elliot Road, MD EL508, Tempe, AZ 85284, USA tel: (602)413-4129, fax: (602)413-7281, email: [email protected] Abstract We describe “WarpNet”, a time-warping algorithm for speech recognition based on neural nets. WarpNet is a self-organizing matching mechanism intended to replace dynamic programming (Dynamic Time Warping or Viterbi-a...