The synthesis and characterization of new 4-[(2-alkyl)-2H-tetrazol-5-yl]phenyl 4-alkyloxybenzoates (5a–i) and 5-{4-[(4-substituted)benzyloxy]phenyl}-2-alkyl-2H-tetrazoles (7a–e) are reported. The reported tetrazoles contain two alkyl chains (six to ten carbon atoms) except for 5h and 7e which have a chiral citronellyl group linked at the N-2 nitrogen atom of the tetrazole ring and 5i having a b...

 In this article, synthesis of the explosive synthesis of 5- picrylamino-1, 2, 3, 4-tetrazole (PAT) from the reaction of 5-amino-1, 2, 3, 4-tetrazole with picryl chloride in different conditions of temperature, with density functional theory method were studied. For this purpose, at first the material contained in the both sides of reaction were geometrically optimized, then th...

Abstract A series of tetrazole-linked dibenzo[b,f][1,4]oxazepines is synthesized through a short sequence involving an Ugi tetrazole reaction. The intermediate undergoes potassium carbonate mediated SNAr cyclization, followed by oxidation to afford the target tricyclic heterocyclic scaffold. optimization, scope and limitations this two-step efficient methodology are investigated. 1000-member li...

Cypermethrin a widely used insecticide of Pyrethroids (type II) group, was administered in mice at two dose levels (1/10 of LD50 i.e. 2.5 mg/kg and 1/5 of LD50 i.e. 5.0 mg/kg) and pharmacodynamic interactions of insecticide were studied with centrally acting drugs viz. pentobarbital sodium, amphetamine, pentylenetetrazole, acepromazine and analgin. Cypermethrin pretreatment potentiated the acti...

Cyclization and chlorination of 2-amino-5-benzyl-4, 5, 6, 7-tetrahydro hydro thieno [3, 2c] pyridine-3carboxamide yielded (3 a-b). Reaction with different substituted pyridines of [3 a-b] yielded 4a (1-4) and 4b (1-2). However reaction of 3a with different substituted 2-amino phenols yielded 4a (5-6). Further 3a yields 4a (7) & 4a (8) from different substituents like o-phenylene diamine and 4-c...

PURPOSE We report here the antimycobacterial activity of some already synthesized tetrazole derivatives containing tetrazole against Mycobacterium tuberculosis strain H37Rv. METHODS In vitro evaluation of the antitubercular activity was carried out within the Tuberculosis Antimicrobial Acquisition & Coordinating Facility (TAACF) screening program for the discovery of novel drugs for the treat...

A series of molybdenum(VI) oxide-organic solids were prepared by hydrothermal reactions employing N-donor tectons, which combine two 1,2,4-triazol-4-yl sites separated by representative aliphatic spacers (ethylene, tr(2)eth; 1,3-propylene, tr(2)pr; trans-1,4-cyclohexanediyl, tr(2)cy; diamondoid 1,3-adamantanediyl, tr(2)ad; 1,6- and 4,9-diamantanediyls, 1,6-tr(2)dia and 4,9-tr(2)dia) and heterof...

A series of 5-(4-alkoxyphenylalkyl)-1H-tetrazole derivatives, containing an oxazole-based group at the alkoxy moiety, was prepared and their antidiabetic effects were evaluated in two genetically obese and diabetic animal models, KKAy mice and Wistar fatty rats. Syntheses were performed by cyclization of the corresponding nitrites reacting with azide compounds. A large number of the 5-(4-alkoxy...

The mol-ecule of the title compound, C(4)H(8)N(6), assumes an approximately planar structure, the methyl C atoms and the C atom to which they are bonded being out of the mean tetrazole ring plane by 0.108 and 0.139, and 0.144 Å, respectively. π-π stacking between parallel tetra-zole rings [centroid-centroid distance = 3.4663 (11) Å] is observed in the crystal structure. Inter-molecular N-H⋯N hy...

An improved method of the synthesis of flavanones catalyzed by pyrrolidine and BF(3) ·Et(2) O has been developed and a lot of flavanones could be easily synthesized via this method. The asymmetric synthesis of flavanone from benzaldehyde and 5-fluoro-2-hydroxyacetophenone has been studied and flavanone with moderate enantioselectivity was obtained in one step.