نتایج جستجو برای: 4 aminoquinolines
تعداد نتایج: 1303665 فیلتر نتایج به سال:
Background: LiveWell Initiative LWI is a self-funded nonprofit social enterprise which thrives on innovation.
BACKGROUND Drug resistance in malaria parasites is extending in the world particularly in chemical synthesized drugs such as 4- aminoquinolines and aminoalcoholes. Employing herbal extracts is encouraged by WHO in the malarious areas. In this study, the effectiveness of ethanolic extract of Artemisia aucheri individually and in combination with chloroquine, has been considered against chloroqui...
The design and synthesis of a series of alkyl 5(6)-substituted benzimidazole-2-carbamates (1-13), 7-chloro-4-(4-substituted phenyl)aminoquinolines (14-16), 1,2-dimethyl-3-methoxy-carbonyl-4,5-disubstituted pyrroles (17-19) and some compounds belonging to the class pimelonitrile (20), dihydroquinoline (21), pyridine (22), pyridoquinoline (23) and tetrahydro-pyrimidine (24) have been carried out ...
The design and synthesis o f a series o f alkyl 5(6)-substituted benzimidazole-2-carbamates (1-13), 7-chloro-4-(4-substituted phenyl)aminoquinolines (14-16), l,2-dimethyl-3-methoxycarbonyl-4,5-disubstituted pyrroles (17—19) and some compounds belonging to the class pimelonitrile (20), dihydroquinoline (21), pyridine (22), pyridoquinoline (23) and tetrahydropyrimidine (24) have been carried out ...
Mutations in the glucose-6-phosphate dehydrogenase (G6PD) gene result in red blood cells with increased susceptibility to oxidative damage. Significant haemolysis can be caused by primaquine and other 8-aminoquinoline antimalarials used for the radical treatment of Plasmodium vivax malaria. The distribution and phenotypes of mutations causing G6PD deficiency in the male population of migrants a...
A heating-induced desulfurization annulation of readily available CF3-imidoyl sulfoxonium ylides and isothiocyanates for the construction 2-trifluoromethylquinolines has been achieved. The developed transformation was performed under metal- additive-free conditions, producing a variety biologically valuable 2-trifluoromethylquinoline derivatives with high efficiency.
BACKGROUND Radical cure of Plasmodium vivax malaria with 8-aminoquinolines (primaquine or tafenoquine) is complicated by haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. G6PD heterozygous females, because of individual variation in the pattern of X-chromosome inactivation (Lyonisation) in erythroid cells, may have low G6PD activity in the majority of their ery...
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