Several characteristics have been predictive of outcome of therapy for relapsed or “primary refractory” acute myelogenous leukemia (AML).’-4 Among these are duration of first complete remission (CR) and the number of, and response to, prior salvage regimens. Using these covariates, we have developed a system that stratifies patients by probability of response to previous salvage agents. This sy...

The response of CR-39 nuclear track detector (TasTrak(®)) to protons in the energy range of 0.92-9.28 MeV has been studied. Previous studies of the CR-39 response to protons have been extended by examining the piece-to-piece variability in addition to the effects of etch time and etchant temperature; it is shown that the shape of the CR-39 response curve to protons can vary from piece-to-piece....

Chromium/phosphorus binary cluster ions, [Cr(n)P(m)](+/-), produced by laser (532nm) ablation on a tablet of well-mixed chromium and red phosphorus powder, were studied with a home-built tandem time-of-flight (TOF) mass spectrometer. The clusters thus formed are mostly rich in phosphorus. There is an odd-even oscillation in the intensity of the [CrP(m)](+) series, i.e. the mass peaks of even m ...

Objective: Increasing an individual’s level of cognitive reserve (CR) has been suggested as a nonpharmacological approach to reducing the risk for Alzheimer’s disease. We examined changes in CR in older adults participating over 4 years in the Tasmanian Healthy Brain Project. Method: A sample of 459 healthy older adults between 50 and 79 years of age underwent a comprehensive annual assessment ...

We report the generation and spectroscopic characterization of a heterobimetallic [(TMC)Fe(III)-O-Cr(III)(OTf)4] species (1) by bubbling O2 into a mixture of Fe(TMC)(OTf)2 and Cr(OTf)2 in NCCH3. Complex 1 also formed quantitatively by adding Cr(OTf)2 to [Fe(IV)(O)(TMC)(NCCH3)](2+). The proposed O2 activation mechanism involves the trapping of a Cr-O2 adduct by Fe(TMC)(OTf)2.

concentrations of six heavy metals including cr, mn, ni, pb, v and zn were determined in topsoil (from 47 grid cells), surface water (4 streams) and groundwater (8 wells and 4 qanats) from an agriculturalarea located at south part of the iranian capital, near the tehran oil refinery. concentrations of the elementswere measured using flame and flameless atomic absorption spectrometry. based on t...

Caloric restriction (CR) is argued to positively affect general health, longevity and the normally occurring age-related reduction of cognition. This issue is well examined, but most studies investigated the effect of short-term periods of CR. Herein, 4 weeks old female mice were fed caloric restricted for 4, 20 and especially for 74 weeks. CR mice received 60% of food eaten by their ad libitum...

Urinary free corticoids (cortisol and cortisone), catecholamines (norepinephrine or NE, epinephrine or E, dopamine or DA, and their O-methoxylated metabolites) as well as creatinine (Cr) were analysed in 42 spontaneously voided urine samples from Large White (LW, n = 20), Meishan (MS, n = 6), and LW x MS (F1, n = 16) lactating sows. The cortisol concentration in the urine of MS (28.1 pg/microgr...

BACKGROUND AND OBJECTIVES Peroral supplementation with trivalent-chromium (Cr) or magnesium (Mg) has been shown to improve insulin resistance (IR). The objective of this study was to determine whether combined peroral supplementation with Cr and Mg improves IR more effectively than Cr or Mg alone. METHODS AND STUDY DESIGN Subjects (n=120, age range 45-59 years old) and diagnosed with IR were ...

Siderophores are a diverse group of low molecular weight biogenic metallophores with a particular affinity for Fe(III) but they also have potential to complex a number of other polyvalent metal cations, including Cr(III). Here we show that two hydroxamate siderophores, desferrioxamine B and rhodotorulic acid, at environmentally relevant concentrations, facilitate the dissolution of hydroxy-Cr(I...