AF8 cells were collected by mitotic detachment or made quiescent by serum restriction. Replated mitotic cells or serum-stimulated quiescent cells were then compared by flow cytofluorometry, with the use of acridine orange staining. Red fluorescence intensity (F ,„„,) was the same in quiescent cells and in cells immediately after mitosis. However, F „¿ „„ increased very rapidly in post...

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RoxA is an extracellular c-type diheme cytochrome secreted by Xanthomonas sp. strain 35Y during growth on rubber. RoxA cleaves poly(cis-1,4-isoprene) to 12-oxo-4,8-dimethyltrideca-4,8-diene-1-al (ODTD). Analysis of the RoxA structure revealed that Phe317 is located in close proximity (≈5 Å) to the N-terminal heme that presumably represents the active site. To find evidence of whether Phe317 is...

Objective—To examine the eVect of concomitant intake of â blockers with angiotensin converting enzyme (ACE) inhibitors, diuretics, or both on plasma renin concentrations in a population based sample (MONICA survey, Augsburg, Germany). Subject and methods—728 individuals were studied, of whom 171 were treated using monotherapy (ACE inhibitor (n = 21), diuretic (n = 10), or â blocker (n = 72)), o...

A number of reports have described the occurrence of liver cell adenomas in women using oral contraceptives. Circum stantial evidence derived from human and early experimental animal data, together with the recent report of Taper [Cancer (Phila.), 42: 462-467, 1978], suggests that oral contraceptive steroids may be liver tumor promoters. The objective of this study was to determine whether the ...

Mutations in the p53 gene are frequent genetic alterations in human hepatocellular carcinomas. We have examined 13 cases of human hepatocellular carcinomas from Germany for the presence of p53 aberrations in exons 4 to 8 of the gene by single-strand conformation polymorphism and restriction fragment-length polymorphism analyses and by sequenc ing of polymerase chain reaction products. Single ba...

Mutations in the p53 gene are frequent genetic alterations in human hepatocellular carcinomas. We have examined 13 cases of human hepatocellular carcinomas from Germany for the presence of p53 aberrations in exons 4 to 8 of the gene by single-strand conformation polymorphism and restriction fragment-length polymorphism analyses and by sequenc ing of polymerase chain reaction products. Single ba...

C10H24F6N6O8SÌ, tetragonal, PA /̂n (no. 86), a = 15.646(1) Â, c = 8.2024(5) Â, V = 2007.9 Â, Ζ = 4, Rgl(F) = 0.052, wRrefiF) = 0.117, T= 233 K. Source of material The racemic title compound was unexpectedly obtained from a mixture of 2-azido-l,3-dimethoxyimidazolium hexafluorophosphate [1], dimethyl acetylenedicarboxylate and copper wire in methanol. Suitable crystals were harvested after allowi...