Drosophila Melanogaster has some 14,000 genes in its genome. Gene sequencing has revealed many new genes that have yet to be studied for function. To narrow this astronomical task Pelement inserts were inserted into different genes on the left arm of chromosome 3. The importance of the gene for cell development was analyzed by inducing mutant expression in the eye. Of the six Bloomington stocks...

Yu, Haiyan, Nobuharu Fujii, Michael F. Hirshman, Jason M. Pomerleau, and Laurie J. Goodyear. Cloning and characterization of mouse 5 -AMP-activated protein kinase 3 subunit. Am J Physiol Cell Physiol 286: C283–C292, 2004. First published September 24, 2003; 10.1152/ajpcell.00319.2003.—Naturally occurring mutations in the regulatory -subunit of 5 -AMP-activated protein kinase (AMPK) can result i...

BACKGROUND Mapping of patient-reported outcomes to the five-dimension EuroQol (EQ-5D) health index is increasingly being used for understanding the relationship of outcomes to health states and for predicting utilities that have application in economic evaluations. The 12-item Multiple Sclerosis Walking Scale (MSWS-12) is a patient-reported outcome that assesses the impact of walking impairment...

BACKGROUND The EQ-5D is a standardised instrument that measures health-related quality-of-life and explores cost-effectiveness of treatments. Malawi is a low-resource country that would benefit from assessment of quality-of-life among individuals living with chronic conditions. Chichewa is the official native language of Malawi. The Chichewa version of the EQ-5D-3L developed by EuroQoL group ha...

BACKGROUND Assessing the impact of disease severity on generic quality of life (QOL) is a critical step in outcomes research and in the development of decision-analytic models structured around health states defined by clinical measures. While data from routine clinical practice found in healthcare registers are increasingly used for research, more attention should be paid to understanding the ...

PURPOSE the aim of the present study was to measure patient perception in the early period after knee replacement surgery and to correlate health status with the surgery-related outcome. METHODS thirty-eight consecutive patients who underwent total knee replacement were evaluated before surgery; at the time Radiographic evaluation was used to assess limb alignment and the Oxford Knee Score (O...

BACKGROUND A five-level version of the EuroQol five-dimensional (EQ-5D) descriptive system (EQ-5D-5L) has been developed, but value sets based on preferences directly elicited from representative general population samples are not yet available. The objective of this study was to develop values sets for the EQ-5D-5L by means of a mapping ("crosswalk") approach to the currently available three-l...

Background: The long-term burden of self-management in type 2 diabetes can impact quality life. Aims: To examine associations between demographic and clinical factors, anxiety/depression perception health people with diabetes. Methods: Retrospective analyses anonymised data from completed trials provided by the subsection Virtual International Cardiovascular Cognitive Trials Archive (VICCTA). D...

Generic health-related quality of life (HRQoL) instruments, such as EQ-5D, are important tools in economic evaluations for measuring disease burden and generating quality-adjusted years (QALYs). Our goal was to compare measurement properties two versions this instrument, the EQ-5D-3L (3L) EQ-5D-5L (5L) atopic dermatitis (AD). We conducted a multicentre cross-sectional survey Hungary, involving ...

Background Preference weights for EQ-5D-3L based on visual analogue scale (VAS) has recently been developed in Iran. The aim of the current study was to compare performance of this value set against the UK VAS-based value set.   Methods The mean scores for all possible 243 health states were compared using Student t test. Absolute agreement and consistency were investigated using concordance co...