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BACKGROUND The prostate component of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial was undertaken to determine whether there is a reduction in prostate cancer mortality from screening using serum prostate-specific antigen (PSA) testing and digital rectal examination (DRE). Mortality after 7-10 years of follow-up has been reported previously. We report extended follow...
BACKGROUND Tuberculosis causes approximately 8.6 million disease episodes and 1.3 million deaths worldwide per year. Although curable with standardized treatment, outcomes for some forms of tuberculosis are improved with adjunctive corticosteroid therapy. Whether corticosteroid therapy would be beneficial in treating people with pulmonary tuberculosis is unclear. OBJECTIVES To evaluate whethe...
Objective—To examine the influence of kinship care on behavioral problems after 18 and 36 months in out-of-home care. Growth in placement of children with kin has occurred despite conflicting evidence regarding its benefits compared to foster care. Design—Prospective cohort study Setting—National Survey of Child & Adolescent Well-Being, October, 1999-March, 2004 Participants—1,309 children ente...
As many particle-associated contaminants and nutrients are supply controlled, the question of particle source is crucial. In addition, sediment storage has important implications for the delivery and fate of pollutants. Increased accumulations of fine sediment ( < 63 Am) in gravel beds not only modify benthic habitat but also increase the retention time of sediment-associated contaminants in th...
High-resolution seismic profiles and sediment cores from Lake Ledro combined with soil and riverbed samples from the lake’s catchment area are used to assess the recurrence of natural hazards (earthquakes and flood events) in the southern Italian Alps during the Holocene. Two welldeveloped deltas and a flat central basin are identified on seismic profiles in Lake Ledro. Lake sediments have been...
BACKGROUND Patients who have had an unprovoked deep venous thrombosis (DVT) or pulmonary embolus (PE) are at a high risk for recurrent venous thromboembolism (VTE). Extended "life-long" anticoagulation has been recommended in these patients. However, the risk benefit ratio of this approach is controversial and the role of the direct oral anticoagulants (DOACs) and aspirin is unclear. Furthermor...
Serum concentration of anti-mullerian hormone (AMH) is used as a biomarker in practical clinics. As bone morphogenetic protein (BMP) cytokines induce AMH expression in human granulosa cells (GC) in vitro, serum concentrations of BMP cytokines and AMH were evaluated whether there would be a relationship between BMP cytokines and AMH. Serum concentrations of BMP-2, -6 -7, AMH and FSH were measure...
A discussion of the difficulties of prototype theories for describing compositional meaning motivates three experiments that inquire how well-defined concepts fare under paradigms that are commonly interpreted to support the prototype view. The stimulus materials include exemplars of prototype categories (sport, vehicle, fruit, vegetable) previously studied by others, and also exemplars of supp...
The use of drugeluting stents (DES) has tackled the "Achilles' heel" of percutaneous coronary interventions (PCI) like no innovation before: the restenosis following initially successful PCI of de novo stenoses. Today, with DES, the pivotal clinical parameter TVF (target vessel failure) is in the upper single- digit range for "standard" lesions and 16% for long lesions. Numerous studies have as...
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