نتایج جستجو برای: 347
تعداد نتایج: 4225 فیلتر نتایج به سال:
RSKB, a 90-kDa ribosomal S6 protein kinase family (RSK) member with two complete catalytic domains connected by a linker, is activated through p38- and ERK-mitogen-activated protein kinases. The N-terminal kinases of RSKs phosphorylate substrates; activation requires phosphorylation of linker and C-terminal kinase sites. Unlike other RSKs, the activation loop phosphorylation sites of both catal...
در فصل اول که مربوط به کلیات مباحث می باشد عناوینی چون : ضرورت موضوع، هدف و انگیزه، تعریف و اقسام نظم بیان و همچنین براهین دیگری که در مورد خداشناسی وجود دارد مورد بحث و بررسی قرار گرفته است. فصل دوم که مربوط به گذا اجمالی به تاریخچه برهان نظم می باشد. فصفل سوم که عهده دار تقریر برهان نظم می باشد در این فصل به انواع تقریرات مورد ارزیابی قرار گرفته ، تفاوتها، نتایج و استدلالهای هر تقریر بیان گرد...
Selective deuterium substitution as ameans of ameliorating clinically relevant pharmacokinetic drug interactions is demonstrated in this study. Carbon-deuterium bonds are more stable than corresponding carbon-hydrogen bonds. Using a precision deuteration platform, the two hydrogen atoms at the methylenedioxy carbon of paroxetine were substituted with deuterium. The new chemical entity, CTP-347 ...
Previous studies have identified two salt bridges in human CFTR chloride ion channels, Arg(352)-Asp(993) and Arg(347)-Asp(924), that are required for normal channel function. In the present study, we determined how the two salt bridges cooperate to maintain the open pore architecture of CFTR. Our data suggest that Arg(347) not only interacts with Asp(924) but also interacts with Asp(993). The t...
Given ∈ [0, 1), the -Relative Error Periodic Pattern Problem (REPP) is the following: INPUT: An n-long sequence S of numbers si ∈ N in increasing order. OUTPUT: The longest -relative error periodic pattern, i.e., the longest subsequence si1 , si2 , . . . , sik of S, for which there exists a number p such that the absolute difference between any two consecutive numbers in the subsequence is at l...
Common mental health consequences following the experience of potentially traumatic events include Posttraumatic Stress Disorder (PTSD) and addictive behaviors. Problematic smartphone use is a newer manifestation of addictive behaviors. People with anxiety severity (such as PTSD) may be at risk for problematic smartphone use as a means of coping with their symptoms. Unique to our knowledge, we ...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید